NCT05154799: DYSENS

Developmental Coordination Disorder

Recruiting now NA Last updated 16 January 2026

What this trial tests

NA trial testing Proprioception and tactile localization with manual or ocular response and/or free hand grasp in Motor Skills Disorders in 280 participants. Currently enrolling.

Timeline

21 December 2021

Primary endpoint
21 January 2027

21 January 2027

Quick facts

Lead sponsor	Hospices Civils de Lyon
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	factorial
Masking	none
Primary purpose	basic science
Enrollment	280
Start date	21 December 2021
Primary completion	21 January 2027
Estimated completion	21 January 2027
Sites	1 location across France

Drugs / interventions tested

• Proprioception and tactile localization with manual or ocular response and/or free hand grasp

Conditions studied

• Motor Skills Disorders — all drugs for Motor Skills Disorders →
• Neurodevelopmental Disorders — all drugs for Neurodevelopmental Disorders →

Sponsor

Hospices Civils de Lyon — full company profile →

Who can join

Adults 9 to 40, any sex, with Motor Skills Disorders or Neurodevelopmental Disorders. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Developmental Coordination Disorder (DCD) corresponds to a clumsiness, a slowness and an inaccuracy of motor performance. This neurodevelopmental disorder affects 6% of school-aged children, and disturbs daily life activities and academic performances. The etiology of DCD is still unknown. An understanding of this disorder is necessary to improve interventions and therefore quality of life of these people.

A deficit of the so-called internal models is the most commonly described hypothesis of DCD. Indeed, children with DCD exhibit difficulties in predictive control. Internal models, useful for motor control, are closely related to the sensory system, as they are elaborated on and constantly fed by sensory feedback. Deficits in sensory performance are described in DCD, mostly in the visual system, which could in turn partly explain poor motor performance. However, visuo-perceptual deficits cannot explain the entire motor difficulties because some activities in daily life, as buttoning a shirt, are often performed without visual control. Although the integrity of proprioceptive and tactile systems is necessary for the building of internal models, and therefore for a stable motor control, these sensory systems have been very little investigated in DCD.

Moreover, using a tool is often disturbed in children with DCD. In neurotypical subjects, tool use induces a plasticity of body representation, as reflected by modifications of movement kinematics after tool use. Proprioceptive abilities are necessary for this update of the body schema. Thus, potential deficits of the proprioceptive system in children with DCD could impair the plastic modification of the body schema, and hence of motor performance, when using a tool. The aim of this study is to identify the main cause of the DCD, both by evaluating the tactile and proprioceptive abilities and by assessing the body schema updating abilities in children with DCD.

While some daily life activities improve with age, some motor difficulties persist in adults with DCD. To our knowledge, perceptual abilities have never been investigated in adults with DCD and it is thus unknown whether perceptual deficits are still present in adulthood. This information could allow us to understand if motor difficulties in adult DCD are caused by enduring perceptual deficits and/or impaired plasticity of body schema. The second aim of this study is to evaluate abilities of perception and of body schema plasticity in adults with DCD.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.