Last reviewed · How we verify
NCT05149534
rTMS-augmented Written Exposure Therapy for PTSD
NA trial testing Written Exposure Therapy in Post Traumatic Stress Disorder in 98 participants. Currently enrolling.
29 January 2027
Quick facts
| Lead sponsor | VA Office of Research and Development |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 98 |
| Start date | 3 January 2022 |
| Primary completion | 29 January 2027 |
| Estimated completion | 29 January 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Written Exposure Therapy
- repetitive transcranial magnetic stimulation
Conditions studied
- Post Traumatic Stress Disorder — all drugs for Post Traumatic Stress Disorder →
Sponsor
VA Office of Research and Development — full company profile →
Who can join
Adults 18 to 60, any sex, with Post Traumatic Stress Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Post-traumatic stress disorder (PTSD) is prevalent and represents a high healthcare burden among Veterans. Repetitive transcranial magnetic stimulation (rTMS) is a brain-based therapy that may be effective for treating PTSD. The theorized mechanism of rTMS is enhancement of emotional flexibility via the dorsolateral prefrontal cortex node of the brain's cognitive control network. Given this mechanism of action, adding rTMS to an evidence-based psychotherapy (EBP) for PTSD may enhance treatment effects. Written exposure therapy (WET) is a brief EBP for PTSD found to reduce attrition compared to lengthier first line treatments. In this study, the investigators will determine if active rTMS added to WET compared with sham rTMS added to WET results in improved PTSD outcomes. The investigators will also determine if emotional flexibility is a mechanism of symptom improvement. This work will improve upon PTSD intervention and inform the mechanism of treatment effectiveness for Veterans suffering from PTSD.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Repetitive transcranial magnetic stimulation for post-traumatic stress disorder in adults.
Brown R, Cherian K, Jones K, Wickham R, et al · · 2024 · cited 6× · PMID 39092744 · DOI 10.1002/14651858.cd015040.pub2 -
Interventional Psychiatry and Emerging Treatments for Posttraumatic Stress Disorder (PTSD): A Systematic Review.
Janssen-Aguilar R, Meshkat S, Al-Shamali HF, Perivolaris A, et al · · 2025 · cited 2× · PMID 40879152 · DOI 10.5152/pcp.2025.241027
Verify or expand the search:
- PubMed search for NCT05149534
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Written Exposure Therapy
Trials testing the same drug.
- NCT07498257 — Adaptation and Randomized Controlled Trial of Written Exposure Therapy for Adolescents · NA · not yet recruiting
- NCT07108608 — Adaptation of Written Exposure Therapy in Substance Treatment · NA · not yet recruiting
- NCT06771817 — Empowering Perinatal Adolescents Through Writing · NA · recruiting
- NCT06571513 — Written Exposure Therapy to Improve Recovery Among Sexual Assault Survivors · NA · completed
- NCT05674617 — PTSD Treatment for Veterans With Serious Mental Illness to Improve Functional Outcomes · NA · recruiting
Other recruiting trials for Post Traumatic Stress Disorder
Currently open trials in the same condition.
- NCT07485231 — Nitric Oxide (NO) and Endothelial Dysfunction in Women With PTSD · NA · recruiting
- NCT07316088 — Determining the Potential for Efficacy of OTX-601 in Reducing PTSD Symptoms · Phase 2 · recruiting
- NCT07227337 — Being Safe, Healthy, And Positively Empowered (BSHAPE) Intervention Study · NA · recruiting
- NCT06988787 — Multifaceted Intervention to Restore Resilience and Overcome Risk · NA · recruiting
- NCT06740487 — Advanced Wireless Augmented Reality-Enhanced Exposure Therapy for Posttraumatic Stress Disorder · NA · recruiting
Other VA Office of Research and Development trials
Trials by the same sponsor.
- NCT07456150 — Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care · Phase 1 · not yet recruiting
- NCT06746727 — The Development of a Transdiagnostic Intervention to Improve Social Functioning and Intimate Relationships Among Veteran · NA · not yet recruiting
- NCT07362576 — Perinatal Peer Support for Veterans With Serious Mental Illness · NA · not yet recruiting
- NCT06766331 — Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans · NA · not yet recruiting
- NCT07397195 — ACT for Veterans With IBD and Mental Health Challenges · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05149534 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by VA Office of Research and Development
- Last refreshed: 12 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05149534.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing