Last reviewed · How we verify
NCT05145595
Pain Sensitivity During Puberty
NA trial testing Thermal Sensory Analyzer in Pain in 36 participants. Completed in 17 July 2024.
17 July 2024
Quick facts
| Lead sponsor | Washington University School of Medicine |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | other |
| Enrollment | 36 |
| Start date | 20 September 2022 |
| Primary completion | 17 July 2024 |
| Estimated completion | 17 July 2024 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Thermal Sensory Analyzer
- Pressure Stimuli
- Mechanical Stimuli
- Pain Ratings
- Thermal pain thresholds
- Pressure pain thresholds (PPT)
- Mechanical temporal summation
- Conditioned pain modulation (CPM) efficiency
- Offset analgesia efficiency
- Cold pain tolerance
Conditions studied
- Pain — all drugs for Pain →
Sponsor
Washington University School of Medicine
Who can join
Adults 9 to 16, any sex, with Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Aim 1- To examine the differences in pain sensitivity between adolescents at early vs. mid pubertal status Aim 2- To determine the relationships between sex hormone levels and pain sensitivity Exploratory Aim 1- To determine the effect of pubertal maturation on pain sensitivity Exploratory Aim 2- To identify parameters related to who will develop chronic pain during puberty Hypothesis 1- Adolescents in early pubertal status will have higher pain ratings and lower pain modulation capabilities compared to adolescents in mid puberal status. Hypothesis 2- Pain sensitivity will be associated with sex hormone levels. Exploratory Hypothesis 1- As adolescents mature, they will have a decrease in pain sensitivity to experimental pain which will be related to changes in sex hormone levels. Exploratory hypothesis 2- Female adolescents with greater pain sensitivity, lower testosterone levels and with a family history of pain would be at a higher risk to develop chronic pain
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The role of puberty in experimental pain sensitivity in healthy adolescent girls.
Nahman-Averbuch H, Banerjee G, Brown J, McMichael A, et al · · 2025 · cited 1× · PMID 40444025 · DOI 10.1097/pr9.0000000000001292
Verify or expand the search:
- PubMed search for NCT05145595
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Washington University School of Medicine trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05145595 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Washington University School of Medicine
- Last refreshed: 9 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05145595.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing