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NCT05139732
Exploring Functional Paralysis with Advanced Magnetic Resonance Modalities
trial testing Magnetic Resonance Imaging (MRI) in Functional Neurological Symptom Disorder in 69 participants. Completed in 8 February 2024.
8 February 2024
Quick facts
| Lead sponsor | Swiss Paraplegic Research, Nottwil |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 69 |
| Start date | 4 November 2022 |
| Primary completion | 8 February 2024 |
| Estimated completion | 8 February 2024 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- Magnetic Resonance Imaging (MRI)
Conditions studied
- Functional Neurological Symptom Disorder — all drugs for Functional Neurological Symptom Disorder →
- Paralysis — all drugs for Paralysis →
- Conversion Disorder with Weakness/Paralysis — all drugs for Conversion Disorder with Weakness/Paralysis →
Sponsor
Swiss Paraplegic Research, Nottwil — full company profile →
Who can join
Adults 18 to 65, any sex, with Functional Neurological Symptom Disorder or Paralysis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In functional neurological disorder (FND), neurological symptoms are present, such as paralysis, weakness and disturbed sensation of limbs, although clinically no abnormalities can be found. It is a poorly understood disorder with uncertain diagnosis, treatment and prognosis. In this study, the subtype functional paralysis is investigated with advanced neuroimaging techniques that go beyond standard clinical examinations. In previous research on FND, healthy volunteers have generally been used as a control group. However, since people with functional paralysis have similar symptoms to people with spinal cord injuries (SCI), it is intended to compare the three groups to find similarities and differences. With the proposed methods, the goal is to gain a detailed understanding of FND regarding nerve cell metabolism, diffusion pathways and neuronal networks involved in cognitive processes such as motor inhibition (reaction or no reaction depending on situation). Neurophysiological data, clinical assessments and questionnaires are carried out in addition to Magnetic Resonance Imaging (MRI). The aim is to enrol 75 participants in this study, i.e. 25 people with FND, 25 people with SCI and 25 healthy control subjects. The overall goal of the study is to find markers for FND for use in future studies to improve diagnosis and individualise therapy recommendation for both people with SCI and people with FND. Therefore, this study is a relevant step to understand FND and to diagnose this specific disease using objective MRI based diagnostic tools.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Revisiting motor inhibition in individuals with functional paralysis and spinal cord injury.
Vallesi V, Galléa C, Sritharan J, Hurni ER, et al · · 2025 · PMID 41113675 · DOI 10.1093/braincomms/fcaf377
Verify or expand the search:
- PubMed search for NCT05139732
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05139732 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Swiss Paraplegic Research, Nottwil
- Last refreshed: 2 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05139732.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing