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NCT05138471
Addition of Transcranial Direct Current Stimulation and Transcutaneous Electrical Nerve Stimulation to an Education and Exercise Program in Subjects With Chronic Pain Due to Knee Osteoarthritis
NA trial testing transcranial direct current stimulation (tDCS) in Osteo Arthritis Knee in 65 participants. Completed in 1 May 2024.
1 March 2024
Quick facts
| Lead sponsor | Universidad de Murcia |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 65 |
| Start date | 17 November 2021 |
| Primary completion | 1 March 2024 |
| Estimated completion | 1 May 2024 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- transcranial direct current stimulation (tDCS)
- TENS
- Exercise and General Education
Conditions studied
- Osteo Arthritis Knee — all drugs for Osteo Arthritis Knee →
- Chronic Pain — all drugs for Chronic Pain →
Sponsor
Universidad de Murcia — full company profile →
Who can join
50 and older, any sex, with Osteo Arthritis Knee or Chronic Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Knee osteoarthritis has a very high prevalence in the population over 50 years of age. Patients with osteoarthritis often suffer from chronic pain that becomes disabling, affecting both quality of life and mental and physical health. This pathology has also been linked to maladaptive plasticity in the brain, which can contribute to chronic pain. Therapies with neuromodulatory approaches, such as transcranial direct current stimulation (tDCS) and peripheral electrical stimulation (TENS), have been used therapeutically to counteract the maladaptive plasticity of the brain. Transcranial therapy and TENS can be a possible effective treatment in the rehabilitation services of the health system for the improvement of chronic pain and quality of life in different pathologies, such as chronic low back pain, fibromyalgia or knee and hip osteoarthritis.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The Efficacy of the Addition of tDCS and TENS to an Education and Exercise Program in Subjects with Knee Osteoarthritis: A Randomized Controlled Trial
Montilla-Herrador J, Lozano-Meca J, Lozano-Guadalajara J, Gacto-Sánchez M. · · 2024
Verify or expand the search:
- PubMed search for NCT05138471
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other recruiting trials for Osteo Arthritis Knee
Currently open trials in the same condition.
- NCT07258693 — Multimodal Treatment of Knee Osteoarthritis: Therapeutic Exercise and Noninvasive Neuromodulation (NESA) Versus Therapeu · NA · active not recruiting
- NCT07141316 — Effects of Blood Flow Restriction Combined With Electrostimulation After Knee Arthroplasty · NA · active not recruiting
- NCT06485843 — An Study to Evaluate Safety and Tolerability of OA-SYS in Subjects With Moderate to Severe Osteoarthritis of the Knee Jo · Phase 2 · recruiting
- NCT06965946 — Intermittent Hypoxia-Hyperoxia Combined With Physical Therapy for Knee Osteoarthritis · NA · recruiting
- NCT06058169 — Effects of Home Base Whole-body Vibration in Osteoarthritis. (VIBE-Rx2) · NA · recruiting
Other Universidad de Murcia trials
Trials by the same sponsor.
- NCT07310459 — Perinatal Risk Factors in Motor Development · not yet recruiting
- NCT06982456 — Manual Therapy Techniques for Cervical Pain: Algometric Evaluation · NA · enrolling by invitation
- NCT06910150 — Effectiveness of a Session of Analgesic Electrostimulation (Invasive and Non-invasive) Applied to the Quadriceps Muscle · NA · enrolling by invitation
- NCT06206499 — Laterally Rotated Flap for Soft Tissue Augmentation Around Maxillary Loaded Osseointegrated Dental Implant · NA · unknown
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05138471 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universidad de Murcia
- Last refreshed: 8 May 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05138471.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing