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NCT05132465: L-HARP
Liverpool-Heart and BRain Project Stroke Cohort
trial in Stroke, Ischemic in 1,655 participants. Completed in 10 June 2024.
10 June 2024
Quick facts
| Lead sponsor | University of Liverpool |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 1,655 |
| Start date | 12 October 2021 |
| Primary completion | 10 June 2024 |
| Estimated completion | 10 June 2024 |
| Sites | 1 location across United Kingdom |
Conditions studied
- Stroke, Ischemic — all drugs for Stroke, Ischemic →
- Transient Ischemic Attack — all drugs for Transient Ischemic Attack →
Sponsor
University of Liverpool
Who can join
Adults 18 to 100, any sex, with Stroke, Ischemic or Transient Ischemic Attack. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
What research question is being addressed? Can improve the prediction of adverse outcomes be improved for people following a stroke to optimise their treatment and care? How is it of relevance and importance to patients and public? Following a stroke, people are at a higher risk of developing certain conditions including heart failure, another stroke and atrial fibrillation, a type of irregular heart rhythm. In the proposed study, the investigators will look at factors which may increase a person's risk of such conditions following stroke. From this, the investigators will determine if risk scores for these conditions can be improved for people post-stroke. This could help doctors decide what treatments are best. Who would be eligible? All adults at participating hospitals who have had an ischaemic stroke (where the stroke is caused by loss of blood flow to the brain) or a transient ischaemic attack ('mini-stroke') confirmed by a stroke doctor. All patients will be asked to take part in the study, or their family members may be asked to provide advice on their behalf if the patient is unable to. Where is the study being conducted? At participating hospitals in England and Wales. What will the participants undergo? At the time of stroke, patients have a lot of information collected about their health, the investigators will copy information from patient's medical records about their health after they agree to take part in the study. Patients or their family members will also be asked to complete some additional brief questionnaires about their quality of life, wellbeing and fatigue. Some questionnaires such as for cognitive function are already collected for patients following a stroke, but where this information has not been collected, it will be collected for the study. The investigators will ask the patients if they can be contacted in 12-months to repeat the questionnaires and information collected about their health.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The Liverpool Heart And bRain Project (L-HARP): Protocol for an Observational Cohort Study of Cardiovascular Risk and Outcomes Following Stroke.
Harrison SL, Lane DA, Buckley BJR, Chatterjee K, et al · · 2022 · cited 1× · PMID 35502192 · DOI 10.2147/vhrm.s357829
Verify or expand the search:
- PubMed search for NCT05132465
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University of Liverpool trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05132465 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Liverpool
- Last refreshed: 21 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05132465.
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