Last reviewed · How we verify
NCT05118100
Effectiveness of Adhesive Containing MDPB
trial testing Clearfil Protect Bond in Secondary Caries in 5,102 participants. Completed in 30 June 2021.
30 June 2021
Quick facts
| Lead sponsor | Radboud University Medical Center |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 5,102 |
| Start date | 1 January 2015 |
| Primary completion | 30 June 2021 |
| Estimated completion | 30 June 2021 |
Drugs / interventions tested
- Clearfil Protect Bond — full drug profile →
- Clearfil SE Bond — full drug profile →
Conditions studied
- Secondary Caries — all drugs for Secondary Caries →
Sponsor
Radboud University Medical Center
Who can join
6 and older, any sex, with Secondary Caries. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
9 general practices in the Netherlands were provided with two composite resin adhesives, each for a period of 9 months. One contained MDPB (Adhesive P), and the other one was used as a control (Adhesive S). Patient's age, SES, and caries risk, as well as tooth type/number, reason for restoration placement, used restorative material and bonding agent, and affected surfaces were recorded. All interventions carried out on these teeth in the next 6 years were extracted from the electronic patient records, along with their date, type, reason, and surfaces. Two dependent variables were defined: general failure, and failure due to secondary caries. All data handling and statistical analyses were carried out in R 4.0.5.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effectiveness of adhesive containing MDPB: A practice-based clinical trial.
Hollanders ACC, Kuper NK, Bronkhorst EM, Laske M, et al · · 2023 · cited 2× · PMID 37394389 · DOI 10.1016/j.dental.2023.06.011
Verify or expand the search:
- PubMed search for NCT05118100
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Secondary Caries
Currently open trials in the same condition.
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- NCT03108586 — Caries Cognition and Identification in Adults · NA · active not recruiting
Other Radboud University Medical Center trials
Trials by the same sponsor.
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- NCT07530263 — Deposition of Inhaled Liposomal Amphotericin B in Chronic Pulmonary Aspergillosis (CPA) · Phase 1 · not yet recruiting
- NCT07532577 — Intranasal Insulin to Prevent Intensive Care Unit Delirium · Phase 2, PHASE3 · not yet recruiting
- NCT07504172 — Real-world Effectiveness and Dosing Patterns of Tirzepatide in People With Obesity · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05118100 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Radboud University Medical Center
- Last refreshed: 11 November 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05118100.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing