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NCT05115968
Single Cell Sequencing of Tonsillar Tissue in Children With OSA
trial testing Tonsillectomy in Obstructive Sleep Apnea of Child in 15 participants. Currently enrolling.
31 December 2025
Quick facts
| Lead sponsor | Chinese University of Hong Kong |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 15 |
| Start date | 1 January 2023 |
| Primary completion | 31 December 2025 |
| Estimated completion | 31 December 2025 |
| Sites | 1 location across Hong Kong |
Drugs / interventions tested
- Tonsillectomy
Conditions studied
- Obstructive Sleep Apnea of Child — all drugs for Obstructive Sleep Apnea of Child →
Sponsor
Chinese University of Hong Kong
Who can join
Adults 6 to 11, any sex, with Obstructive Sleep Apnea of Child. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Obstructive sleep apnoea (OSA) in children is a prevalent sleep disorder, and is characterised by repetitive complete or partial upper airway obstruction during sleep. It is an important disease as it is associated with a large spectrum of end-organ morbidities. Adenotonsillar hypertrophy is the commonest cause of OSA in children, however, the cause of the lymphoid tissue hypertrophy in some individuals but not the others remains unknown. To address the cellular heterogeneity and immune cell involvement in adenotonsillar hypertrophy, here, we propose to employ single-cell sequencing analysis to identify the cell-specific expression patterns associated with the disease, which will enhance our understanding of the pathogenesis of tonsillar hypertrophy in children with OSA and may provide directions for development of novel therapy.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05115968
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Related trials
Other trials of Tonsillectomy
Trials testing the same drug.
- NCT06606262 — Tonsillectomy Versus Tonsillotomy in the Treatment of Recurrent Acute Tonsillitis · NA · recruiting
- NCT06119841 — Tonsillectomy and Expansion Sphincter Pharyngoplasty Operations · NA · completed
- NCT04657549 — Tonsil Surgery in Recurrent or Chronic Tonsillitis · NA · completed
- NCT04543708 — Surgical Treatment of Tonsillar Abscess · NA · unknown
- NCT04314492 — Intracapsular Tonsillectomy in the Treatment of Obstructive Sleep Apnea in Adults · NA · completed
Other recruiting trials for Obstructive Sleep Apnea of Child
Currently open trials in the same condition.
- NCT07345312 — BodySleep Algorithm for OSA Diagnosis in Children · recruiting
- NCT07380321 — Diaphragm Ultrasound İn Children With OSAS · recruiting
- NCT06634264 — Comparison of Two Reeducation Methods in Children With Persistent Sleep Apnea, a Randomized Controlled Trial · NA · recruiting
- NCT06367400 — Validation of Pediatric Sleep Questionnaire on a Swedish Cohort · recruiting
- NCT05908110 — Evidence-based Pediatric Obstructive Sleep Apnea Detection · NA · active not recruiting
Other Chinese University of Hong Kong trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05115968 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Chinese University of Hong Kong
- Last refreshed: 13 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05115968.
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