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NCT05106270
The Impact of Atrial Pressure Change Before and After Combined Procedure
trial testing Atrial pressure measurement using transseptal puncture sheath in Atrial Fibrillation in 100 participants. Currently enrolling.
10 November 2023
Quick facts
| Lead sponsor | Shanghai 10th People's Hospital |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 100 |
| Start date | 10 November 2021 |
| Primary completion | 10 November 2023 |
| Estimated completion | 10 November 2027 |
| Sites | 1 location across China |
Drugs / interventions tested
- Atrial pressure measurement using transseptal puncture sheath
Conditions studied
- Atrial Fibrillation — all drugs for Atrial Fibrillation →
- Heart Failure — all drugs for Heart Failure →
Sponsor
Shanghai 10th People's Hospital
Who can join
18 and older, any sex, with Atrial Fibrillation or Heart Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
One-stop procedure combining catheter ablation (CA) and left atrial appendage closure (LAAC) has been a feasible treatment for patients with atrial fibrillation at high risk of stroke and/or bleeding. Although it could achieve considerable rhythm control and stroke prophylaxis, a number of patients has experienced progressive heart failure after the procedure. Notably, previous studies indicate that both pulmonary vein isolation by CA and LAAC could significantly increase left atrial pressure, while currently no study has investigated left atrial pressure change in patients underwent combined procedure. The investigators hypothesise that combined procedure would significantly increase left atrial pressure and subsequently deteriorate cardiac function. Therefore, the investigators aim to measure the left and right atrial pressure change before and after CA and LAAC in combined procedure, and investigate the influence of the pressure change on clinical outcomes.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05106270
- Europe PMC full search
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05106270 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Shanghai 10th People's Hospital
- Last refreshed: 2 September 2022
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