NCT05079945: TRACTOCORD

Tractography and Diffusion Tensor Imaging of the Human Spinal Cord in Healthy Subjects : Anatomical Atlas

Completed NA Last updated 3 September 2025

What this trial tests

NA trial testing Spinal cord Tractography in order to differentiate spinal tracts. in Healthy Volunteer in 49 participants. Completed in 30 April 2022.

Timeline

5 February 2022

Primary endpoint
30 April 2022

30 April 2022

Quick facts

Lead sponsor	Hospices Civils de Lyon
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	basic science
Enrollment	49
Start date	5 February 2022
Primary completion	30 April 2022
Estimated completion	30 April 2022
Sites	1 location across France

Drugs / interventions tested

• Spinal cord Tractography in order to differentiate spinal tracts.

Conditions studied

• Healthy Volunteer — all drugs for Healthy Volunteer →

Sponsor

Hospices Civils de Lyon — full company profile →

Who can join

Adults 18 to 85, any sex, with Healthy Volunteer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Today, Spinal cord pathologies, whether are tumoral, vascular, traumatic, malformative, inflammatory, or degenerative still constitute a major medico-surgical challenge due to the particular anatomy of the spinal cord. Indeed, the spinal fibers (whether they have a sensory or motor function) are all condensed in an extremely small volume. To date, there is no reliable technique to know the precise position of the spinal tracts specifically involved in the sensory and motor functions of the upper and lower limbs.

The purpose of this study is to evaluate the feasibility for differentiating spinal tracts by tractography from a cerebral Diffusion tensor imaging (DTI) Magnetic Resonance Imaging (MRI) sequence (associated with an anatomical sequence) by performing a stitching process with spinal cord DTI MRI sequence, in healthy subjects. The criterion of differentiation of the tracts will be assessed by highlighting already known cerebral tracts (cortico-spinal fibers, spinothalamic, posterior cord) and which will be monitored at the spinal level.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Full cervical cord tractography: A new method for clinical use.
   Dauleac C, Frindel C, Pélissou-Guyotat I, Nicolas C, et al · · 2022 · cited 11× · PMID 36237419 · DOI 10.3389/fnana.2022.993464