Who is sponsoring NCT05072652?

NCT05072652 is sponsored by University of Central Florida.

What drugs are being tested in NCT05072652?

Interventions in NCT05072652: Neuromuscular Electrical Stimulation, Action Observation + Mental Imagery.

What condition does NCT05072652 study?

NCT05072652 studies Weakness, Muscle, Muscle Weakness, Muscle Loss, Muscle Atrophy, Injury, Knee.

Is NCT05072652 still recruiting?

NCT05072652 is currently completed. Last updated 19 August 2022.

Last reviewed 2022-08-19 · How we verify

NCT05072652: STILL

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Short Term Immobilization of the Lower Limb

Completed NA Last updated 19 August 2022

What this trial tests

NA trial testing Neuromuscular Electrical Stimulation in Weakness, Muscle in 50 participants. Completed in 1 July 2022.

Timeline

11 October 2021

Primary endpoint
1 June 2022

1 July 2022

Quick facts

Lead sponsor	University of Central Florida
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	50
Start date	11 October 2021
Primary completion	1 June 2022
Estimated completion	1 July 2022
Sites	1 location across United States

Drugs / interventions tested

Neuromuscular Electrical Stimulation
Action Observation + Mental Imagery

Conditions studied

Weakness, Muscle — all drugs for Weakness, Muscle →
Muscle Weakness — all drugs for Muscle Weakness →
Muscle Loss — all drugs for Muscle Loss →
Muscle Atrophy — all drugs for Muscle Atrophy →

Sponsor

University of Central Florida

Who can join

Adults 18 to 40, any sex, with Weakness, Muscle or Muscle Weakness. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to determine the effects of one week of knee-joint immobilization on muscle size, strength, neuromuscular function, and brain function. In addition, the effects of two different interventions (i.e., neuromuscular electrical stimulation and action observation/mental imagery) throughout immobilization will be determined. Following the immobilization period, participants that have lost strength will be rehabilitated with twice weekly resistance training sessions, and sex-based differences in rehabilitation timelines will be examined.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Combined action observation and mental imagery versus neuromuscular electrical stimulation as novel therapeutics during short-term knee immobilization.
Harmon KK, Girts RM, Rodriguez G, Beausejour JP, et al · · 2024 · cited 2× · PMID 38687158 · DOI 10.1113/ep091827
Correlation of Physical Activity Level with Muscle Strength and Size During One Week of Knee Joint Immobilization.
Harmon KK, Pourhatami Z, Malinowski D, Girts RM, et al · · 2025 · PMID 40566442 · DOI 10.3390/jfmk10020192

Verify or expand the search:

Other trials of Neuromuscular Electrical Stimulation

Trials testing the same drug.

NCT06856720 — NMES, Exercise, and Glycemic Control in Older Adults With Type 2 Diabetes · NA · enrolling by invitation
NCT07143630 — Abdominal Electrical Stimulation for Balance and Muscle Thickness in Stroke Patients · NA · active not recruiting
NCT06601088 — Achilles Tendon Rupture - Intervention With Electrical Stimulation · NA · not yet recruiting
NCT06872697 — Impact of Whole Body Vibration on Muscle Function and Respiratory Parameters in Intensive Care Patients · NA · completed
NCT06887855 — Enhancing Post-Stroke Dysphagia Rehabilitation · NA · recruiting

Other recruiting trials for Weakness, Muscle

Currently open trials in the same condition.

NCT06441422 — Blood Flow Restriction Training for People With Disabilities · NA · recruiting
NCT05877846 — Precision Medicine and Physical Function · NA · recruiting
NCT05725928 — Assisted Ambulation to Improve Health Outcomes for Older Medical Inpatients · NA · recruiting
NCT06538974 — Adherence to Long-term Exoskeleton Rehabilitation to Treat Lower Limb Weakness and / or Deficiencies in Adult Population · NA · recruiting

Other University of Central Florida trials

Trials by the same sponsor.

NCT07203430 — Biopsychosocial Factors and Muscle Morphology After a Resistance Exercise · NA · completed
NCT07214883 — UCF MammoChat: Image Repository · recruiting
NCT06999057 — Quadriceps Motor Unit Adaptation to Simulated Knee Injury · NA · not yet recruiting
NCT06979713 — Yoga, Education, and Nidra (YEN) for Chronic Low Back Pain: A Pilot Study on Pain Modulation, Well-Being, and Sleep · NA · not yet recruiting
NCT06512168 — Measuring Aided Language Development · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05072652 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Central Florida
Last refreshed: 19 August 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05072652.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing