NCT05046743 is a NA clinical trial of Colonic gas load in Healthy Volunteers, sponsored by Hospital Universitari Vall d'Hebron Research Institute.

Who is sponsoring NCT05046743?

NCT05046743 is sponsored by Hospital Universitari Vall d'Hebron Research Institute.

What drugs are being tested in NCT05046743?

Interventions in NCT05046743: Colonic gas load, Sham load.

What condition does NCT05046743 study?

NCT05046743 studies Healthy Volunteers.

Is NCT05046743 still recruiting?

NCT05046743 is currently completed. Last updated 29 September 2021.

Last reviewed 2021-09-29 · How we verify

NCT05046743

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Intestinal Dysmotility: Effect of Colonic Load

Completed NA Last updated 29 September 2021

What this trial tests

NA trial testing Colonic gas load in Healthy Volunteers in 16 participants. Completed in 30 May 2021.

Timeline

1 February 2021

Primary endpoint
30 May 2021

30 May 2021

Quick facts

Lead sponsor	Hospital Universitari Vall d'Hebron Research Institute
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	basic science
Enrollment	16
Start date	1 February 2021
Primary completion	30 May 2021
Estimated completion	30 May 2021
Sites	1 location across Spain

Drugs / interventions tested

Colonic gas load
Sham load

Conditions studied

Healthy Volunteers — all drugs for Healthy Volunteers →

Sponsor

Hospital Universitari Vall d'Hebron Research Institute

Who can join

Adults 18 to 80, any sex, with Healthy Volunteers. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Abnormal motility patterns in the jejunum can be detected in patients with prominent colonic distension, and it is not clear whether these abnormalities reflect a primary jejunal dysfunction or are due to a reflex distortion. The aim of the study is to determine the effect of colonic filling on jejunal postprandial motility using high-resolution manometry. Healthy subjects will be studied following a controlled, parallel, randomized, single-blind experimental design. On the study day, nutrients will be continuously infused in the proximal jejunum (2 Kcal/min) during a 2-h period to induce a steady-state postprandial motor pattern. Jejunal motility will be concomitantly recorded using a water-perfused, high-resolution manometry catheter. After 1 hour of postprandial recording (basal period), a gas mixture will be infused during 7.5 minutes via a rectal tube (720 mL or sham infusion), and jejunal motility will be recorded for another hour.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Effect of colonic distension on small bowel motility measured by jejunal high-resolution manometry.
Alcalá-Gonzalez LG, Malagelada C, Livovsky DM, Azpiroz F. · · 2022 · cited 10× · PMID 35318777 · DOI 10.1111/nmo.14351

Verify or expand the search:

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Other Hospital Universitari Vall d'Hebron Research Institute trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05046743 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hospital Universitari Vall d'Hebron Research Institute
Last refreshed: 29 September 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05046743.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing