NCT05041712 (BEAM) is a clinical trial in Extracorporeal Membrane Oxygenation, sponsored by Johns Hopkins University.

Who is sponsoring NCT05041712?

NCT05041712 is sponsored by Johns Hopkins University.

What condition does NCT05041712 study?

NCT05041712 studies Extracorporeal Membrane Oxygenation, Children, Neurologic Injury.

Is NCT05041712 still recruiting?

NCT05041712 is currently completed. Last updated 4 June 2025.

Last reviewed 2025-06-04 · How we verify

NCT05041712: BEAM

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Biomarkers of Brain Injury in Critically-Ill Children on Extracorporeal Membrane Oxygenation

Completed Last updated 4 June 2025

What this trial tests

trial in Extracorporeal Membrane Oxygenation in 455 participants. Completed in 5 May 2025.

Timeline

6 December 2019

Primary endpoint
24 January 2025

5 May 2025

Quick facts

Lead sponsor	Johns Hopkins University
Status	Completed
Study type	OBSERVATIONAL
Enrollment	455
Start date	6 December 2019
Primary completion	24 January 2025
Estimated completion	5 May 2025
Sites	11 locations across United States

Conditions studied

Extracorporeal Membrane Oxygenation — all drugs for Extracorporeal Membrane Oxygenation →
Children — all drugs for Children →
Neurologic Injury — all drugs for Neurologic Injury →

Sponsor

Johns Hopkins University

Who can join

Adults 2 Days to 18, any sex, with Extracorporeal Membrane Oxygenation or Children. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The BEAM study is a multicenter, prospective, observational study in children supported on extracorporeal membrane oxygenation (ECMO). The primary goals of this study are to develop and refine a brain injury multimarker panel for accurate neurologic monitoring at the bedside and early classification of mortality and disability outcomes of critically ill children supported on ECMO.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

ECMO-induced coagulopathy: strategic initiatives for research and clinical practice (a workshop report of the NHLBI).
Levy JH, Alexander PMA, Wolberg AS, McCarty OJT, et al · · 2025 · cited 11× · PMID 40766281 · DOI 10.1016/j.bvth.2025.100064
Definitions of adverse events associated with extracorporeal membrane oxygenation in children: results of an international Delphi process from the ECMO-CENTRAL ARC.
Alexander PMA, Di Nardo M, Combes A, Vogel AM, et al · · 2024 · cited 7× · PMID 39299748 · DOI 10.1016/s2352-4642(24)00132-9
Lessons Learned in Neurodevelopmental Outcomes Research in Children Following Extracorporeal Membrane Oxygenation.
Monteleone M, Salorio C. · · 2023 · cited 2× · PMID 36745174 · DOI 10.1097/ana.0000000000000878
Plasma Biomarkers of Brain Injury in Critically Ill Children Receiving Extracorporeal Membrane Oxygenation.
Friedman ML, Bell MJ, Brooks BA, Himebauch AS, et al · · 2026 · PMID 41770542 · DOI 10.1001/jamapediatrics.2026.0015

Verify or expand the search:

Other recruiting trials for Extracorporeal Membrane Oxygenation

Currently open trials in the same condition.

NCT06862700 — Effect of Reduced Vasopressors on Mortality in ECMO-supported Cardiogenic Shock Patients · recruiting
NCT06560164 — Restrictive Versus Liberal Thresholds for RBC Transfusion in ECMO · NA · recruiting
NCT06369584 — Prone Position During ECMO in Pediatric Patients With Severe ARDS · NA · recruiting
NCT05574296 — Hydrogen's Feasibility and Safety as a Therapy in ECPR · Phase 1 · recruiting
NCT06660784 — Mechanism of Nitric Oxide on Ventilator-induced Diaphragm Dysfunction with Extracorporeal Membrane Lung Assistance · active not recruiting

Other Johns Hopkins University trials

Trials by the same sponsor.

NCT06236542 — Tracheostomy Robotics and Cutting-edge Health Education for Airway Safety · NA · not yet recruiting
NCT07532252 — Daridorexant for Alcohol Use Disorder · Phase 2 · not yet recruiting
NCT06687655 — Impact of Exogenous Ketones on Sleep Apnea · Phase 1, PHASE2 · not yet recruiting
NCT07079111 — 3D Printed Occlusal Splints for Intraoperative Use · NA · not yet recruiting
NCT02998502 — The Use of a FDA Cleared, Drug-free, Breathing System for Anxiety and Panic Disorders in Children and Teens · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05041712 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Johns Hopkins University
Last refreshed: 4 June 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05041712.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing