NCT05040022 is a Phase 4 clinical trial of Pneumoperitoneum pressure 10 mmHg in Quality of Recovery, sponsored by Pontificia Universidade Catolica de Sao Paulo.

Who is sponsoring NCT05040022?

NCT05040022 is sponsored by Pontificia Universidade Catolica de Sao Paulo.

What drugs are being tested in NCT05040022?

Interventions in NCT05040022: Pneumoperitoneum pressure 10 mmHg, Pneumoperitoneum pressure 14 mmHg.

What condition does NCT05040022 study?

NCT05040022 studies Quality of Recovery, Postoperative Pain, Postoperative Nausea and Vomiting, Neuromuscular Blockade.

Is NCT05040022 still recruiting?

NCT05040022 is currently status unknown. Last updated 20 September 2021.

Last reviewed 2021-09-20 · How we verify

NCT05040022

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Quality of Recovery Under Low or Standard Pneumoperitoneum Pressure

Status unknown Phase 4 Last updated 20 September 2021

What this trial tests

Phase 4 trial testing Pneumoperitoneum pressure 10 mmHg in Quality of Recovery in 80 participants. Status unknown.

Timeline

1 October 2021

Primary endpoint
5 January 2022

15 January 2022

Quick facts

Lead sponsor	Pontificia Universidade Catolica de Sao Paulo
Phase	Phase 4
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	prevention
Enrollment	80
Start date	1 October 2021
Primary completion	5 January 2022
Estimated completion	15 January 2022
Sites	1 location across Brazil

Drugs / interventions tested

Pneumoperitoneum pressure 10 mmHg — full drug profile →
Pneumoperitoneum pressure 14 mmHg — full drug profile →

Conditions studied

Quality of Recovery — all drugs for Quality of Recovery →
Postoperative Pain — all drugs for Postoperative Pain →
Postoperative Nausea and Vomiting — all drugs for Postoperative Nausea and Vomiting →
Neuromuscular Blockade — all drugs for Neuromuscular Blockade →

Sponsor

Pontificia Universidade Catolica de Sao Paulo — full company profile →

Who can join

Adults 18 to 70, any sex, with Quality of Recovery or Postoperative Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The use of low-pressure pneumoperitoneum seems to be able to reduce complications such as postoperative pain. However, the quality of evidence for most studies evaluating this relationship is considered low. The absence of concealment of pneumoperitoneum pressure and the lack of description of neuromuscular blockade characteristics are the main causes of bias. The purpose of this study will be to evaluate by means of a prospective, randomized and double-blinded trial, the quality of recovery (QoR-15) questionnaire of patients undergoing laparoscopic cholecystectomy under moderate neuromuscular blockade, using low pneumoperitoneum pressure or "standard" pressure. Eighty patients submitted to laparoscopic cholecystectomy and randomly distributed in two groups will be included: low pneumoperitoneum pressure (10 mmHg) or "standard" pressure (14 mmHg). The value of abdominal pressure will be kept hidden for all participants, except for the nurse responsible for the operating room. Moderate neuromuscular blockade will be maintained according to Train-of-four count (TOFc) = 3 for all cases.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Deep neuromuscular blockade in adults undergoing an abdominal laparoscopic procedure.
Bijkerk V, Jacobs LM, Albers KI, Gurusamy KS, et al · · 2024 · cited 2× · PMID 38288876 · DOI 10.1002/14651858.cd013197.pub2

Verify or expand the search:

Other recruiting trials for Quality of Recovery

Currently open trials in the same condition.

NCT06584825 — Enhanced Vitals Monitoring After Major Surgery Trial · NA · recruiting
NCT06948383 — SPSIPB vs. SAPB in Breast Surgery · NA · active not recruiting

Other Pontificia Universidade Catolica de Sao Paulo trials

Trials by the same sponsor.

NCT05053594 — Different Doses of Neostigmine for Reversal of Moderate Neuromuscular Blockade in Children · Phase 4 · unknown
NCT05037006 — Three Different Doses of Neostigmine on the Reversal of Cisatracurium-induced Moderate Neuromuscular Blockade · Phase 4 · unknown
NCT04920682 — Reversal of Moderate or Superficial Neuromuscular Blockade Induced by Cisatracurium · Phase 4 · completed
NCT04146090 — Low-pressure vs Standard-pressure in Laparoscopic Cholecystectomy · NA · completed
NCT03035942 — Quality of Recovery After Dexamethasone, Ondansetron or Placebo Intrathecal Morphine Administration · Phase 4 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05040022 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Pontificia Universidade Catolica de Sao Paulo
Last refreshed: 20 September 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05040022.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing