NCT04999137 (REVISTA-DOSE) is a Phase 2 clinical trial of Vitamin C in Sepsis, sponsored by Liverpool School of Tropical Medicine.

Who is sponsoring NCT04999137?

NCT04999137 is sponsored by Liverpool School of Tropical Medicine.

What drugs are being tested in NCT04999137?

Interventions in NCT04999137: Vitamin C, Vitamin B1.

What condition does NCT04999137 study?

NCT04999137 studies Sepsis, Septic Shock, HIV.

Is NCT04999137 still recruiting?

NCT04999137 is currently status unknown. Last updated 8 September 2021.

Last reviewed 2021-09-08 · How we verify

NCT04999137: REVISTA-DOSE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Evaluation of Safety and Dosing of a Vitamin C Bundle for Sepsis Treatment in Africa

Status unknown Phase 2 Last updated 8 September 2021

What this trial tests

Phase 2 trial testing Vitamin C in Sepsis in 60 participants. Status unknown.

Timeline

1 September 2021

Primary endpoint
29 December 2021

29 December 2021

Quick facts

Lead sponsor	Liverpool School of Tropical Medicine
Phase	Phase 2
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	60
Start date	1 September 2021
Primary completion	29 December 2021
Estimated completion	29 December 2021
Sites	2 locations across Uganda

Drugs / interventions tested

Vitamin C — full drug profile →
Vitamin B1 — full drug profile →

Conditions studied

Sepsis — all drugs for Sepsis →
Septic Shock — all drugs for Septic Shock →
HIV — all drugs for HIV →

Sponsor

Liverpool School of Tropical Medicine

Who can join

18 and older, any sex, with Sepsis or Septic Shock. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Open-label phase 2a Randomized Controlled Trial (RCT) assessing the pharmacokinetics of two different doses of intravenous vitamin C given alongside vitamin B1 in adult medical patients with sepsis and hypotension.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Early administration of Vitamin C in patients with sepsis or septic shock in emergency departments: A multicenter, double blinded, randomized controlled trial: The C-EASIE trial protocol.
Vandervelden S, Wauters L, Breuls J, Fieuws S, et al · · 2021 · cited 5× · PMID 34739527 · DOI 10.1371/journal.pone.0259699

Verify or expand the search:

Other trials of Vitamin C

Trials testing the same drug.

NCT07476443 — Renoprotective Role of Vitamin C and Coenzyme Q10 in Nephrotoxicity · Phase 2, PHASE3 · not yet recruiting
NCT07414693 — Effect of Vitamin C on Length of Hospital Stay in Children With Severe Pneumonia · Phase 4 · recruiting
NCT06971315 — Impact of Vitamin C on Pain Detection and Tolerance Threshold · NA · completed
NCT06794255 — Exploratory Study on the Role of Vitamin C in Promoting Health in Middle-Aged and Elderly Adults · NA · recruiting
NCT07341308 — Does Vitamin C Increase the Body Heat Generated By The Nervous System? · NA · recruiting

Other recruiting trials for Sepsis

Currently open trials in the same condition.

NCT07507877 — Infraclavicular Axillary Vein Collapsibility Index as a Predictor of Fluid Responsiveness · recruiting
NCT07154615 — Assessing Immune Dysfunction in Sepsis · recruiting
NCT07419802 — OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study · recruiting
NCT07351344 — African Survey on Sepsis Knowledge (ASK) · recruiting
NCT07448805 — Accuracy and Safety of the Syai Tag System for Continuous Glucose Monitoring in Intensive Internal Care Unit · NA · recruiting

Other Liverpool School of Tropical Medicine trials

Trials by the same sponsor.

NCT07403318 — Mobile Health Supported Self-care Among Tertiary Education Students in Zimbabwe · NA · not yet recruiting
NCT06944275 — Characterising the Loss of Haemostasis in Haemorrhagic Fever With Renal Syndrome · not yet recruiting
NCT07504926 — A Randomised Feasibility Study of CPAP in Large Airway Collapse · NA · not yet recruiting
NCT07248423 — Start Taking Action for Tuberculosis in Kids · NA · not yet recruiting
NCT07420881 — Start4All - Start Taking Action for TB Diagnosis (DARE-TB) · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04999137 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Liverpool School of Tropical Medicine
Last refreshed: 8 September 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04999137.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing