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Vitamin B1
Vitamin B1 (thiamine) acts as a coenzyme in carbohydrate metabolism and nervous system function.
Vitamin B1 (thiamine) acts as a coenzyme in carbohydrate metabolism and nervous system function. Used for Thiamine (Vitamin B1) deficiency, Beriberi, Wernicke-Korsakoff syndrome.
At a glance
| Generic name | Vitamin B1 |
|---|---|
| Also known as | group B, Vitamin B1 or Thiamin or Thiamine or Aneurin, Thiamine, Thiamin |
| Sponsor | Shanghai Zhongshan Hospital |
| Drug class | Vitamin B complex |
| Target | Thiamine pyrophosphate-dependent enzymes |
| Modality | Small molecule |
| Therapeutic area | Nutritional deficiency / Neurology |
| Phase | FDA-approved |
Mechanism of action
Thiamine is converted to thiamine pyrophosphate (TPP), which serves as an essential cofactor for several key enzymes involved in carbohydrate metabolism, including pyruvate dehydrogenase and transketolase. It is critical for energy production in cells and proper functioning of the nervous system, particularly in nerve impulse transmission and myelin formation.
Approved indications
- Thiamine (Vitamin B1) deficiency
- Beriberi
- Wernicke-Korsakoff syndrome
- Nutritional supplementation
Common side effects
- Hypersensitivity reactions
- Pruritus
- Urticaria
- Anaphylaxis (rare)
Key clinical trials
- Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers (PHASE1)
- The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease (EARLY_PHASE1)
- Iron and Immune Response to Vaccine (IRONMUM) (NA)
- Synbiotic Supplement With Botanical Extracts for Gut Microbiota Balance in Irritable Bowel Syndrome (NA)
- Type 2 Diabetes and Blood Brain Barrier Improvement (EARLY_PHASE1)
- Clinical Trial On The Effect Of Artisterol On Risk Factors In Individuals With Suboptimal Cholesterol Levels (NA)
- Assessing the Impact of Herbal Supplement on Fatigue and Disease Activity in SLE: Results From an 8-Week Randomized Trial (NA)
- A Clinical Study to Evaluate the Efficacy of a Nutritional Supplement to Improve Carotenoid Content as Measured by a Non-invasive Hyperspectral Absorption Device (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Vitamin B1 CI brief — competitive landscape report
- Vitamin B1 updates RSS · CI watch RSS
- Shanghai Zhongshan Hospital portfolio CI