NCT04995289

Prone Position During ECMO in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Hypoxaemic Patient

Completed Last updated 13 August 2021

What this trial tests

trial testing Prone position on ECMO patient in SARS CoV 2 Infection in 23 participants. Completed in 30 January 2021.

Timeline

1 January 2020

Primary endpoint
30 January 2021

30 January 2021

Quick facts

Lead sponsor	Mohammed VI University Hospital
Status	Completed
Study type	OBSERVATIONAL
Enrollment	23
Start date	1 January 2020
Primary completion	30 January 2021
Estimated completion	30 January 2021
Sites	1 location across Morocco

Drugs / interventions tested

• Prone position on ECMO patient

Conditions studied

• SARS CoV 2 Infection — all drugs for SARS CoV 2 Infection →
• Hypoxemic Respiratory Failure — all drugs for Hypoxemic Respiratory Failure →

Sponsor

Mohammed VI University Hospital

Who can join

Eligibility, any sex, with SARS CoV 2 Infection or Hypoxemic Respiratory Failure. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Introduction:

The main manifestation of COVID-19 pneumonia is acute respiratory distress syndrome (ARDS), which in some cases can be more severe than intubation, extracorporeal membrane venous oxygenation (VV-ECMO) to ensure hematosis. Despite support from VV-ECMO, some patients may remain hypoxemic. One possible therapeutic procedure for these patients is the application of the prone position.

Objective:

The main aim of this study was to investigate the modification of the PaO2/FiO2 ratio, the compliance of the respiratory system in VV-ECMO with refractory hypoxemia. The secondary objective was to evaluate the safety and feasibility of the inclined position for ECMO.

Methods:

the investigators reviewed the electronic records and lists of all 23 COVID-19 patients. were placed for the first time in PP with an average duration of 16 h . patient characteristics, pre-ECMO characteristics, ventilator/ECMO settings, and changes in ventilator/ECMO settings and blood gas analysis before and after PP.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Prone position during ECMO in patients with COVID-19 in Morocco: Case series.
   Oujidi Y, Bensaid A, Melhoaui I, Jakhjoukh DD, et al · · 2021 · cited 3× · PMID 34484734 · DOI 10.1016/j.amsu.2021.102769