NCT06326762

Gap CO2 in Septic Patient to Predict Cardiomyopathy Septic

Completed Last updated 22 March 2024

What this trial tests

trial testing comparaison in Gap co2 in 98 participants. Completed in 30 October 2023.

Timeline

1 January 2023

Primary endpoint
30 October 2023

30 October 2023

Quick facts

Lead sponsor	Mohammed VI University Hospital
Status	Completed
Study type	OBSERVATIONAL
Enrollment	98
Start date	1 January 2023
Primary completion	30 October 2023
Estimated completion	30 October 2023
Sites	1 location across Morocco

Drugs / interventions tested

• comparaison

Conditions studied

• Gap co2 — all drugs for Gap co2 →
• Cardiac Output, Low — all drugs for Cardiac Output, Low →
• Cardiac Defect — all drugs for Cardiac Defect →

Sponsor

Mohammed VI University Hospital

Who can join

18 and older, any sex, with Gap co2 or Cardiac Output, Low. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

the investigators included 98 patients admitted for sepsis and septic shock (68.4% men, 31.6% women) with an average age of 60.42 years ± 15.13, ranging from 21 to 96 years. The average length of hospital stay was 7.53 days. The most noted medical histories were diabetes (38.8%), hypertension (28.6%), and renal insufficiency (17.1%). Regarding laboratory findings: the mean white blood cell count was 15,985.16 cells/mm³, the mean C-reactive protein (CRP) level was 227.69 mg/L, and the mean procalcitonin level was 50.43 µg/L. In terms of blood gas analysis: the mean lactate level was 3.67 mmol/L, and the mean PCO2 gap (DELTAPCO2) was 4.85. All our patients were continuously monitored by pulse wave analysis: the mean cardiac output was 5.69 L/min, and the mean cardiac index was 4.14 L/s/m² All our patients underwent an echocardiogram, which is a routine examination in our department and is performed at the patient's bedside. The average left ventricular ejection fraction (LVEF) was 51.73%, and the average subaortic peak velocity (ITV) was 14.66 cm.

Subsequently. the investigators examined the clinical and paraclinical profile of patients with septic cardiomyopathy. the investigators identified 19 patients with this condition, while 79 patients did not exhibit cardiac involvement. The percentage was significantly higher in the population with cardiac involvement, accounting for 28.3%. Among the patients with cardiac involvement, 76.5% had a PCO2 gap (DELTAPCO2) ≥ 6 mmHg, a significantly reduced cardiac output with an average of 3.3 L/min, and a predominantly low cardiac index, with 64.3% having an index \< 2.2 L/min/m². The mortality rate was significantly increased at 73.7%.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.