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NCT04982419: RICH
Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial
Phase 2, PHASE3 trial testing Remote ischemic preconditioning in Acute Kidney Injury in 240 participants. Currently enrolling.
31 March 2028
Quick facts
| Lead sponsor | VA Office of Research and Development |
|---|---|
| Phase | Phase 2, PHASE3 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 240 |
| Start date | 1 November 2021 |
| Primary completion | 31 March 2028 |
| Estimated completion | 31 March 2029 |
| Sites | 3 locations across United States |
Drugs / interventions tested
- Remote ischemic preconditioning
- Sham remote ischemic conditioning
Conditions studied
- Acute Kidney Injury — all drugs for Acute Kidney Injury →
- Heart Failure — all drugs for Heart Failure →
- Contrast Induced Nephropathy — all drugs for Contrast Induced Nephropathy →
- Coronary Angiography — all drugs for Coronary Angiography →
Sponsor
VA Office of Research and Development — full company profile →
Who can join
18 and older, any sex, with Acute Kidney Injury or Heart Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a prospective, double-blind, sham-controlled, multicenter, randomized clinical trial is to study the effects of remote ischemic preconditioning on contrast-associated acute kidney injury, functional capacity, and major adverse kidney events in in patients with congestive heart failure undergoing cardiac catheterization and/or percutaneous coronary intervention.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04982419
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Remote ischemic preconditioning
Trials testing the same drug.
- NCT06170944 — Effect of Remote Ischemic Preconditioning on Collaterals of Atherosclerosis Stroke · NA · recruiting
- NCT05990907 — Influence of RIC on the Orthostatic Competence of the Microcirculation · NA · unknown
- NCT05733208 — The Effect of Remote Ischemic Preconditioning on Myocardial Injury After Noncardiac Surgery · NA · active not recruiting
- NCT05567341 — Remote Ischemic Preconditioning in Vestibular Schwannoma Surgery · NA · unknown
- NCT05364333 — Remote Ischemic Preconditioning and Acute Kidney Injury in HTX · NA · completed
Other recruiting trials for Acute Kidney Injury
Currently open trials in the same condition.
- NCT07273838 — Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome · Phase 2 · recruiting
- NCT07262320 — Epidemiology and Processes of Care for Renal Replacement Therapy in Acute Kidney Injury in Latin America · recruiting
- NCT07351149 — Postoperative Acute Kidney Injury in Children Undergoing Major Non-cardiac Surgery · recruiting
- NCT07215702 — A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kid · Phase 2 · recruiting
- NCT06654193 — Allogeneic HB-adMSCs vs Placebo for the Treatment of Acute Kidney Injury · Phase 1, PHASE2 · recruiting
Other VA Office of Research and Development trials
Trials by the same sponsor.
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- NCT06746727 — The Development of a Transdiagnostic Intervention to Improve Social Functioning and Intimate Relationships Among Veteran · NA · not yet recruiting
- NCT07362576 — Perinatal Peer Support for Veterans With Serious Mental Illness · NA · not yet recruiting
- NCT06766331 — Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans · NA · not yet recruiting
- NCT07397195 — ACT for Veterans With IBD and Mental Health Challenges · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04982419 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by VA Office of Research and Development
- Last refreshed: 15 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04982419.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing