NCT04975750 (PRIME) is a NA clinical trial of Problem solving intervention in Mental Disorders, sponsored by Karolinska Institutet.

Who is sponsoring NCT04975750?

NCT04975750 is sponsored by Karolinska Institutet.

What drugs are being tested in NCT04975750?

Interventions in NCT04975750: Problem solving intervention, Care as usual.

What condition does NCT04975750 study?

NCT04975750 studies Mental Disorders.

Is NCT04975750 still recruiting?

NCT04975750 is currently status unknown. Last updated 27 March 2024.

Last reviewed 2024-03-27 · How we verify

NCT04975750: PRIME

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A Problem Solving Intervention Involving Employees at Risk of Sick Leave Due to Common Mental Disorders

Status unknown NA Last updated 27 March 2024

What this trial tests

NA trial testing Problem solving intervention in Mental Disorders in 170 participants. Status unknown.

Timeline

16 August 2021

Primary endpoint
31 December 2024

31 December 2024

Quick facts

Lead sponsor	Karolinska Institutet
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	170
Start date	16 August 2021
Primary completion	31 December 2024
Estimated completion	31 December 2024
Sites	1 location across Sweden

Drugs / interventions tested

Problem solving intervention
Care as usual — full drug profile →

Conditions studied

Mental Disorders — all drugs for Mental Disorders →

Sponsor

Karolinska Institutet

Who can join

Adults 18 to 59, any sex, with Mental Disorders. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The overall aim of this randomized controlled trial is to evaluate the effectiveness of a problem-solving intervention for the prevention of sick leave among employees with early signs of CMDs. The intervention is delivered by first-line managers and a 30% reduction in sick leave days is expected in the experimental condition compared to treatment-as-usual, during the 12- months follow-up.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Prevention of sick leave at the workplace: design of a cluster-randomized controlled trial of a problem-solving intervention among employees with common mental disorders.
Björk Brämberg E, Arapovic-Johansson B, Bültmann U, Svedberg P, et al · · 2021 · cited 5× · PMID 34565357 · DOI 10.1186/s12889-021-11786-6

Verify or expand the search:

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Other Karolinska Institutet trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04975750 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Karolinska Institutet
Last refreshed: 27 March 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04975750.

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