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NCT04971096
Relationship Between Gut Microbiome, Probiotics, and Mild Cognitive Impairment
NA trial testing PS23 live in Mild Cognitive Impairment (MCI) in 10 participants. Terminated before completion.
16 January 2024
Quick facts
| Lead sponsor | Mackay Memorial Hospital |
|---|---|
| Phase | NA |
| Status | Terminated |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | other |
| Enrollment | 10 |
| Start date | 1 April 2022 |
| Primary completion | 16 January 2024 |
| Estimated completion | 16 January 2024 |
| Sites | 1 location across Taiwan |
Drugs / interventions tested
- PS23 live
- PS23 heat-treated
- Placebo
Conditions studied
- Mild Cognitive Impairment (MCI) — all drugs for Mild Cognitive Impairment (MCI) →
Sponsor
Mackay Memorial Hospital
Who can join
Adults 40 to 80, any sex, with Mild Cognitive Impairment (MCI). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study is to evaluate whether the consumption of probiotics can improve the symptoms of patients with mild cognitive impairment; also evaluate the effects of probiotics on patients' blood, oxidation and stress related indicators.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Safety Evaluation and Anti-Inflammatory Efficacy of <i>Lacticaseibacillus paracasei</i> PS23.
Li CH, Chen TY, Wu CC, Cheng SH, et al · · 2022 · cited 35× · PMID 36614167 · DOI 10.3390/ijms24010724
Verify or expand the search:
- PubMed search for NCT04971096
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of PS23 live
Trials testing the same drug.
- NCT04452253 — Psychiatric Symptoms in Employees Experiencing High Levels of Stress Before and After the Intake of Probiotics · NA · completed
Other recruiting trials for Mild Cognitive Impairment (MCI)
Currently open trials in the same condition.
- NCT07516119 — Predicting Pre-dementia · recruiting
- NCT07526740 — Brain Stimulation and Cognitive Training for MCI · NA · recruiting
- NCT07101380 — Feasibility Study of 'SuperBrain BOOM' for Mild Cognitive Impairment Patients · NA · recruiting
- NCT07420426 — Instant Message-delivered Personalised Acceptance and Commitment Therapy (IMPACT) for Neuropsychiatric Symptoms in Perso · NA · recruiting
- NCT07286448 — Personalized Digital Training for COGnitive FITness in Mild Cognitive Impairment · NA · recruiting
Other Mackay Memorial Hospital trials
Trials by the same sponsor.
- NCT07370285 — AI-Supported Empathy Mapping to Enhance Communication and Grit in Pediatric Nursing Students · NA · not yet recruiting
- NCT07537816 — Effects of Vadadustat on Anemia, Quality of Life, and Inflammation in Dialysis Patients · Phase 4 · not yet recruiting
- NCT07479654 — AI-Enabled Frailty Risk Prediction in Adult Congenital Heart Disease · NA · not yet recruiting
- NCT05483634 — Compare Vaginal Estrogen and Platelet-rich Plasma Over Women With Genitourinary Syndrome of Menopause · not yet recruiting
- NCT07118267 — The Intervention of Lactobacillus Plantarum Probiotics in Adult Autistic Spectrum Disorders · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04971096 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mackay Memorial Hospital
- Last refreshed: 8 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04971096.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing