NCT04967872

Perioperative Management of Risk Factors in the Elderly Patients

Completed NA Last updated 15 April 2025

What this trial tests

NA trial testing Implementing risk management and control plan for the elderly during perioperative period in Perioperative Cardiavascular Complication in 4,782 participants. Completed in 31 March 2024.

Timeline

1 September 2021

Primary endpoint
31 March 2024

31 March 2024

Quick facts

Lead sponsor	Ailin Luo
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	4,782
Start date	1 September 2021
Primary completion	31 March 2024
Estimated completion	31 March 2024
Sites	1 location across China

Drugs / interventions tested

• Implementing risk management and control plan for the elderly during perioperative period

Conditions studied

• Perioperative Cardiavascular Complication — all drugs for Perioperative Cardiavascular Complication →
• Peroperative Complication — all drugs for Peroperative Complication →
• Perioperative Pulmonary Complication — all drugs for Perioperative Pulmonary Complication →
• Perioperative Neurological Complication — all drugs for Perioperative Neurological Complication →

Sponsor

Ailin Luo — full company profile →

Who can join

65 and older, any sex, with Perioperative Cardiavascular Complication or Peroperative Complication. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In 2017, the number of operations on hospitalized patients in China was more than 57 million, of which more than 20 million were performed on elderly patients (≥65 years of age). As of the end of 2017, there were 143 million elderly people over 65 years old in China, of which 26 million people were 80 years old and over, accounting for 1.8% of the country's total population, and this proportion is increasing. More and more elderly patients need surgery. A study showed that compared with the 65-79-year-old population, the probability of myocardial infarction after orthopedic surgery in patients over 80 years of age increased by 2.7 times, the probability of lung infection increased by 3.5 times, and the mortality rate increased by 3.4 times. The inherent risks of surgery and increased postoperative complications in elderly patients are closely related to factors such as senile syndrome.

Geriatric syndrome refers to the deterioration of the function of various organ systems as the age increases, and a series of non-specific symptoms and signs appear in the elderly, including weakness, comorbidities, cognitive dysfunction and so on. These symptoms increase with age, seriously impairing the quality of life of the elderly and increasing their perioperative risk. Taking frailty as an example, the incidence of frailty among the 65-70 years old population is 3.2%, 71-74 years old is 5.3%, 75-79 years old is 9.5%, 80-84 years old is 16.3%, and\> 85 years old is 25.1. %. On the other hand, the physical functions of the elderly are constantly degrading with age. Take skeletal muscle as an example. After the age of 50, the skeletal muscle mass decreases by 1%-2% every year with the increase of age. The chronic muscle loss of people over 60 years old is estimated to be 30%, and the elderly people over 80 years old lose up to 50%. It can be seen that the elderly patients are a special group of elderly patients, which have their particularity compared with the low-age elderly groups. Therefore, the establishment of a perioperative risk warning and control system and technical system for elderly patients to deal with the unpredictable perioperative risks caused by their weakness, comorbidities, and physical hypofunction, and to provide safety guarantees for elderly surgical patients has become an urgent problem for geriatrics.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Prognostic significance of preoperative nutritional status for postoperative acute kidney injury in older patients undergoing major abdominal surgery: a retrospective cohort study.
   Sun R, Zhou Z, Li X, Xu Q, et al · · 2024 · cited 15× · PMID 37921644 · DOI 10.1097/js9.0000000000000861
2. Association Between Preoperative Cognitive Performance and Postoperative Delirium in Older Patients: Results From a Multicenter, Prospective Cohort Study, and a Mendelian Randomization Study.
   Sun R, Li S, Yang C, Huang G, et al · · 2025 · cited 1× · PMID 40686922 · DOI 10.1002/mco2.70302