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NCT04860661: EKET
Esketamine on Postpartum Depression in Cesarean Section Women
NA trial testing Esketamine in Esketamine in 336 participants. Completed in 31 March 2024.
31 March 2024
Quick facts
| Lead sponsor | Ailin Luo |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | prevention |
| Enrollment | 336 |
| Start date | 1 May 2021 |
| Primary completion | 31 March 2024 |
| Estimated completion | 31 March 2024 |
| Sites | 1 location across China |
Drugs / interventions tested
- Esketamine (ESKETAMINE) — full drug profile →
- Normal saline
Conditions studied
- Esketamine — all drugs for Esketamine →
- Postpartum Depression — all drugs for Postpartum Depression →
Sponsor
Ailin Luo — full company profile →
Who can join
Adults 18 to 40, female only, with Esketamine or Postpartum Depression. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study was to explore the preventive effect of esketamine on postpartum depression (PPD) in cesarean section, and to evaluate the safety of the drug
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Prophylactic esketamine to reduce postpartum depression in primiparae: A multicentre, double-blind, randomised clinical trial.
Chu T, Peng X, Wan K, Li M, et al · · 2026 · PMID 41607308 · DOI 10.1097/eja.0000000000002348
Verify or expand the search:
- PubMed search for NCT04860661
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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- NCT07227454 — A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder · Phase 3 · recruiting
- NCT06788444 — Efficacy of Esketamine for Patients With Irritable Bowel Syndrome · NA · recruiting
- NCT07179913 — The Improvement of Low-dose Esketamine on Postoperative Depression in Patients Undergoing Bariatric Surgery With Preoper · Phase 4 · not yet recruiting
Other recruiting trials for Esketamine
Currently open trials in the same condition.
- NCT07247968 — Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic Study · EARLY_PHASE1 · recruiting
- NCT07230171 — The Efficacy and Safety of Short Term S-ketamine Infusion as an Adjunctive Therapy in Patients With Fibromyalgia · NA · recruiting
- NCT07050212 — Application of Remimazolam, Dexmedetomidine, and Esketamine in Pediatric Preoperative Sedation · NA · recruiting
- NCT06853431 — Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoper · Phase 4 · recruiting
- NCT06773143 — Effect of Subanesthetic Dose of Esketamine on Sleep Quality · NA · recruiting
Other Ailin Luo trials
Trials by the same sponsor.
- NCT06721988 — Effect of Preventive Analgesia with Oxycodone and Parecoxib Sodium on the Chronification of Acute Post-operative Pain · NA · not yet recruiting
- NCT05810363 — The Safety of Etomidate - Propofol Mixture vs Propofol in Total Intravenous Anesthesia During Abdominal Surgery · NA · completed
- NCT04967872 — Perioperative Management of Risk Factors in the Elderly Patients · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04860661 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ailin Luo
- Last refreshed: 6 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04860661.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing