Last reviewed · How we verify
NCT04956549: RAATE-MCI
Reducing African American's Alzheimer's Risk Through Exercise-Mild Cognitive Impairment (RAATE-MCI)
NA trial testing Physical activity program in Dementia of Alzheimer Type in 144 participants. Currently enrolling.
31 March 2026
Quick facts
| Lead sponsor | Pennington Biomedical Research Center |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 144 |
| Start date | 1 June 2021 |
| Primary completion | 31 March 2026 |
| Estimated completion | 31 March 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Physical activity program
- Successful Aging
Conditions studied
- Dementia of Alzheimer Type — all drugs for Dementia of Alzheimer Type →
Sponsor
Pennington Biomedical Research Center — full company profile →
Who can join
60 and older, any sex, with Dementia of Alzheimer Type. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The RAATE-MCI proposal is designed to determine the effects of physical activity on risk factors for Alzheimer's Disease in older African American adults. The study will compare a physical activity program to an active control group. RAATE-MCI is a 52-week randomized controlled trial. 144 African American adults aged 60 and older will be recruited.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Immunosenescence in aging and neurodegenerative diseases: evidence, key hallmarks, and therapeutic implications.
Chen Z, Mao Z, Tang W, Shi Y, et al · · 2025 · cited 4× · PMID 41299782 · DOI 10.1186/s40035-025-00517-1 -
Exercise Effects on Cognition in Older African Americans: A Pilot Randomized Trial.
Gwizdala KL, Brouillete R, Beyl R, Johnson W, et al · · 2022 · cited 2× · PMID 35936770 · DOI 10.3389/fnagi.2022.921978
Verify or expand the search:
- PubMed search for NCT04956549
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Physical activity program
Trials testing the same drug.
- NCT06844786 — SCORE! ACTIVE Trial · NA · recruiting
- NCT05425498 — The Effects of Physical Activity Behavior Change in Kidney Transplant Recipients · NA · completed
- NCT05298930 — Feasibility Study to Assess an Adapted Physical Activity Program in Children, Adolescents and Young Adults Requiring Hem · NA · completed
- NCT04986332 — Multidimensional Approach for COPD and High Complexity · NA · recruiting
- NCT07373431 — Biomarkers for Epilepsy Development and the Effect of Physical Exercise in Children With Autism · NA · completed
Other recruiting trials for Dementia of Alzheimer Type
Currently open trials in the same condition.
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- NCT04240561 — Characterizing Variability in Hearing Aid Outcomes in Among Older Adults With Alzheimer's Dementia · NA · recruiting
- NCT05893524 — Uppsala-Dalarna Dementia and Gait Project · recruiting
Other Pennington Biomedical Research Center trials
Trials by the same sponsor.
- NCT07530718 — Body Composition Outcomes in MS Patients · not yet recruiting
- NCT07095972 — Continuous Glucose Monitoring in Metabolic Surgery · NA · not yet recruiting
- NCT07139821 — Dietary Iron Requirements · recruiting
- NCT07318064 — Ultra-processed Food Consumption and Health Pilot Study · NA · not yet recruiting
- NCT07305753 — CanCan Body Composition Study · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04956549 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Pennington Biomedical Research Center
- Last refreshed: 17 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04956549.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing