Last reviewed · How we verify
NCT04941950
A Digital Intervention to Prevent the Initiation of Opioid Misuse in Adolescents in School-based Health Centers
NA trial testing PlaySmart in Opioid Misuse in 533 participants. Completed in 1 March 2025.
1 March 2025
Quick facts
| Lead sponsor | Trustees of Dartmouth College |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 533 |
| Start date | 19 October 2021 |
| Primary completion | 1 March 2025 |
| Estimated completion | 1 March 2025 |
| Sites | 15 locations across United States |
Drugs / interventions tested
- PlaySmart
- Video Game Control
Conditions studied
- Opioid Misuse — all drugs for Opioid Misuse →
Sponsor
Trustees of Dartmouth College
Who can join
Adults 16 to 19, any sex, with Opioid Misuse. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The primary hypothesis of this study is that at 3 months, there will be a higher proportion of intervention participants vs. control participants who report greater risk of harm from misuse of prescription opioids AND heroin.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
A digital health game to prevent opioid misuse and promote mental health in adolescents in school-based health settings: Protocol for the PlaySmart game randomized controlled trial.
Pendergrass Boomer TM, Hoerner LA, Fernandes CF, Maslar A, et al · · 2023 · cited 4× · PMID 37683047 · DOI 10.1371/journal.pone.0291298 -
A videogame for perceived risk of harm from opioid misuse in adolescents: a randomized controlled trial.
Boomer T, Hoerner L, Larkin K, Maciejewski K, et al · · 2026 · PMID 41635738 · DOI 10.1038/s44360-025-00010-z
Verify or expand the search:
- PubMed search for NCT04941950
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of PlaySmart
Trials testing the same drug.
- NCT04109599 — A Digital Intervention to Prevent Initiation of Opioid Misuse in Adolescents in School-based Health Centers · NA · completed
Other recruiting trials for Opioid Misuse
Currently open trials in the same condition.
- NCT06489769 — Opioid Misuse in Patients with Cancer · recruiting
- NCT05333341 — Pain Care at Home to Amplify Function (Pain CHAMP) · NA · active not recruiting
- NCT05548582 — Reduced Opioid Prescription After Laparoscopic Hysterectomy · NA · active not recruiting
- NCT05141266 — Healthy Opioid Prescription Engagement · NA · active not recruiting
Other Trustees of Dartmouth College trials
Trials by the same sponsor.
- NCT04646460 — Context Interventions: Social Modeling and Initial Treatment Experience · NA · not yet recruiting
- NCT04669093 — Individual Differences in Placebo Analgesic Effects · NA · not yet recruiting
- NCT07528378 — Manipulating Social Percepts During fMRI · not yet recruiting
- NCT04650841 — The Role of the Opioid System in Placebo Effects on Pain and Social Rejection · EARLY_PHASE1 · not yet recruiting
- NCT07454733 — Do Video Recordings of Multidisciplinary Clinics Improve Quality of Life for People With ALS and Their Caregivers? · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04941950 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Trustees of Dartmouth College
- Last refreshed: 3 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04941950.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing