Who is sponsoring NCT04941157?

NCT04941157 is sponsored by University of Alabama at Birmingham.

What drugs are being tested in NCT04941157?

Interventions in NCT04941157: Cerebrospinal Fluid Drain Placement.

What condition does NCT04941157 study?

NCT04941157 studies Spinal Cord Ischemia.

Is NCT04941157 still recruiting?

NCT04941157 is currently completed. Last updated 10 January 2025.

Last reviewed 2025-01-10 · How we verify

NCT04941157

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Prophylactic vs Therapeutic Cerebrospinal Fluid Drain Placement During Endovascular Thoracoabdominal Aortic Aneurysm Repair

Completed NA Last updated 10 January 2025

What this trial tests

NA trial testing Cerebrospinal Fluid Drain Placement in Spinal Cord Ischemia in 20 participants. Completed in 1 May 2024.

Timeline

1 October 2022

Primary endpoint
1 May 2024

1 May 2024

Quick facts

Lead sponsor	University of Alabama at Birmingham
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	20
Start date	1 October 2022
Primary completion	1 May 2024
Estimated completion	1 May 2024
Sites	2 locations across United States

Drugs / interventions tested

Cerebrospinal Fluid Drain Placement

Conditions studied

Spinal Cord Ischemia — all drugs for Spinal Cord Ischemia →

Sponsor

University of Alabama at Birmingham

Who can join

Adults 18 to 100, any sex, with Spinal Cord Ischemia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a pilot study to be performed at the University of Alabama at Birmingham (UAB) and the University of Massachusetts to determine the feasibility and develop the processes for a future randomized controlled trial to evaluate the occurrence of spinal cord ischemia after endovascular thoracoabdominal aneurysm repair using prophylactic cerebrospinal fluid drains versus no pre-emptive drain. The research question to be addressed is as follows: In the setting of a comprehensive spinal cord ischemia prevention protocol, do prophylactic CSF drains decrease the rate of spinal cord ischemia (SCI) in patients undergoing endovascular thoracoabdominal aneurysm repair?

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Prevention and Management of Spinal Cord Ischemia After Aortic Surgery: An Umbrella Review.
Brotis AG, Kalogeras A, Bareka M, Arnaoutoglou E, et al · · 2025 · cited 1× · PMID 40309856 · DOI 10.3390/brainsci15040409
Spinal cord protection: lessons learned from endovascular repair.
Tenorio ER, Oderich GS. · · 2023 · cited 1× · PMID 37817855 · DOI 10.21037/acs-2023-scp-0049

Verify or expand the search:

Other University of Alabama at Birmingham trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04941157 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Alabama at Birmingham
Last refreshed: 10 January 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04941157.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing