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NCT04941040
Opioid Free VS Opioid Anesthesia for Craniotomies
Phase 1 trial testing Opioid free anesthetics in Supratentorial Neoplasms in 60 participants. Completed in 3 October 2021.
3 October 2021
Quick facts
| Lead sponsor | Kasr El Aini Hospital |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 60 |
| Start date | 5 July 2021 |
| Primary completion | 3 October 2021 |
| Estimated completion | 3 October 2021 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Opioid free anesthetics — full drug profile →
- Opioid Anesthetics — full drug profile →
Conditions studied
- Supratentorial Neoplasms — all drugs for Supratentorial Neoplasms →
Sponsor
Kasr El Aini Hospital
Who can join
Adults 18 to 60, any sex, with Supratentorial Neoplasms. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Hemodynamic control during craniotomies can be a bit hectic specially during periods of intense noxious stimulation. For long anesthesiologists used high doses of opioids such as fentanyl and remifentanyl to provide analgesia with a good hemodynamic control during intraoperative period in patients undergoing craniotomies. However, the use of opioids was not devoid of side effects. Exploring other anesthetic plans using multiple opioid free anesthetic adjuvants that have analgesic effects given together in small doses appear to be appealing plan. This idea is the basis of our proposed study in which we compare the hemodynamic effects of using opioid free anesthesia versus opioid anesthesia in cranial surgeries.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04941040
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04941040 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Kasr El Aini Hospital
- Last refreshed: 19 October 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04941040.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing