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NCT04935619
Extended Effects of Cannabis Abstinence on Clinical Symptoms and Cognition in Depression
NA trial testing Contingency Reinforcement in Cannabis Use in 52 participants. Currently enrolling.
30 June 2027
Quick facts
| Lead sponsor | Centre for Addiction and Mental Health |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 52 |
| Start date | 21 July 2021 |
| Primary completion | 30 June 2027 |
| Estimated completion | 31 August 2027 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Contingency Reinforcement
- Non-Contingency Reinforcement
Conditions studied
- Cannabis Use — all drugs for Cannabis Use →
- Major Depressive Disorder — all drugs for Major Depressive Disorder →
- Cognitive Impairment — all drugs for Cognitive Impairment →
Sponsor
Centre for Addiction and Mental Health — full company profile →
Who can join
Adults 18 to 55, any sex, with Cannabis Use or Major Depressive Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The prevalence of major depressive disorder (MDD) is \~5.0%, and rates of co-occurring SUDs in these patients approach 40-50%. Specifically, rates of co-morbid cannabis use disorder (CUD) in patients with MDD are elevated 2-3 fold compared to 2.9% in the general population, and is associated with poorer treatment outcomes and impaired cognitive and psychosocial functioning in comparison to MDD patients without CUD. Most studies of cannabis use in MDD are cross-sectional in design, and therefore causal relationships are unclear. This study investigates the effects of cannabis abstinence over a 28-day period in patients with MDD with co-occurring CUD using a randomized controlled design, namely contingent reinforcement.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04935619
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Centre for Addiction and Mental Health trials
Trials by the same sponsor.
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- NCT07105449 — THC Titration of High-Potency Cannabis Concentrates · NA · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04935619 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Centre for Addiction and Mental Health
- Last refreshed: 24 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04935619.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing