NCT04921748 is a clinical trial of Neurorehabilitation in Parkinson Disease, sponsored by IRCCS National Neurological Institute "C. Mondino" Foundation.

Who is sponsoring NCT04921748?

NCT04921748 is sponsored by IRCCS National Neurological Institute "C. Mondino" Foundation.

What drugs are being tested in NCT04921748?

Interventions in NCT04921748: Neurorehabilitation.

What condition does NCT04921748 study?

NCT04921748 studies Parkinson Disease, Freezing of Gait.

Is NCT04921748 still recruiting?

NCT04921748 is currently completed. Last updated 15 June 2021.

Last reviewed 2021-06-15 · How we verify

NCT04921748

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Neurorehabilitation of Sequence Effect in Parkinson's Disease

Completed Last updated 15 June 2021

What this trial tests

trial testing Neurorehabilitation in Parkinson Disease in 43 participants. Completed in 28 February 2021.

Timeline

1 August 2019

Primary endpoint
31 January 2021

28 February 2021

Quick facts

Lead sponsor	IRCCS National Neurological Institute "C. Mondino" Foundation
Status	Completed
Study type	OBSERVATIONAL
Enrollment	43
Start date	1 August 2019
Primary completion	31 January 2021
Estimated completion	28 February 2021
Sites	1 location across Italy

Drugs / interventions tested

Neurorehabilitation

Conditions studied

Parkinson Disease — all drugs for Parkinson Disease →
Freezing of Gait — all drugs for Freezing of Gait →

Sponsor

IRCCS National Neurological Institute "C. Mondino" Foundation

Who can join

Adults 18 to 80, any sex, with Parkinson Disease or Freezing of Gait. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The sequence effect (SE), defined as a reduction in amplitude of repetitive movements, is a common clinical feature of Parkinson's disease (PD), being a major contributor to freezing of gait (FOG). During walking, SE manifests as a step-by-step reduction in step length when approaching a turn or gait destination (dSE). The investigators studied the effect of a 4-week rehabilitation program on the destination sequence effect in patients affected by Parkinson's disease with and without Freezing of Gait. All subjects were evaluated with inertial gait analysis for dSE recording.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

The Effects of Intensive Neurorehabilitation on Sequence Effect in Parkinson's Disease Patients With and Without Freezing of Gait.
Putortì A, Corrado M, Avenali M, Martinelli D, et al · · 2021 · cited 3× · PMID 34557151 · DOI 10.3389/fneur.2021.723468

Verify or expand the search:

Other trials of Neurorehabilitation

Trials testing the same drug.

NCT05300867 — Robotic Rehabilitation Treatment of Stroke Patients · NA · completed
NCT05889169 — Stroke-induced Immunodepression in Neurorehabilitation · completed
NCT04587349 — Follow-up Study of the Effectiveness of Virtual Reality Therapy in Patients With Stroke · NA · completed
NCT04367194 — Objective Examination and Rehabilitation Treatment of Patients With BPPV · NA · completed
NCT03424538 — The Effect of Neurorehabilitation Therapy on Postural Control, Mobility and Quality of Life in Multiple Sclerosis Patien · NA · completed

Other recruiting trials for Parkinson Disease

Currently open trials in the same condition.

NCT07399496 — Accelerated TMS for Apathy in PD · NA · recruiting
NCT07371338 — Phase 1 Clinical Trial to Evaluate the Safety, Efficacy, and Pharmacokinetics of IPS101A in Parkinson's Disease Patients · Phase 1 · recruiting
NCT07442370 — The Effect of Functional Rotational Exercises on Fall Risk and Mobility in Parkinson's Disease Patients · NA · recruiting
NCT06848205 — Percept Transitions in FOG and PD · NA · recruiting
NCT07432958 — A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (P · Phase 2 · recruiting

Other IRCCS National Neurological Institute "C. Mondino" Foundation trials

Trials by the same sponsor.

NCT06820411 — A Pilot Study to Assess Optimal Prevention and Outcome Improvement in Young Ischemic Stroke · NA · active not recruiting
NCT06983119 — Case-Finding for Neurocognitive Disorders in Pavia · NA · recruiting
NCT06453863 — Effects of Biofeedback Footwear in Parkinson's Disease: Assessment of Functional Motor Abilities and Locomotion · NA · not yet recruiting
NCT06715436 — Multiple Sclerosis and the Effects of Ketogenic Diet Therapy · NA · recruiting
NCT07442916 — Non-Invasive Brain Stimulation as Add-on Treatment in Chronic Migraine With Medication Overuse · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04921748 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by IRCCS National Neurological Institute "C. Mondino" Foundation
Last refreshed: 15 June 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04921748.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing