Last reviewed · How we verify
NCT07442916
Non-Invasive Brain Stimulation as Add-on Treatment in Chronic Migraine With Medication Overuse
NA trial testing Active rTMS Motor Cortex Face in Chronic Migraine in 60 participants. Completed in 30 January 2026.
30 January 2026
Quick facts
| Lead sponsor | IRCCS National Neurological Institute "C. Mondino" Foundation |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 2 January 2024 |
| Primary completion | 30 January 2026 |
| Estimated completion | 30 January 2026 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Active rTMS Motor Cortex Face
- Active rTMS - Motor Cortex Forearm
- Sham rTMS
Conditions studied
- Chronic Migraine — all drugs for Chronic Migraine →
- Medication Overuse Headache — all drugs for Medication Overuse Headache →
Sponsor
IRCCS National Neurological Institute "C. Mondino" Foundation
Who can join
Adults 18 to 80, any sex, with Chronic Migraine or Medication Overuse Headache. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This randomized, double-blind, sham-controlled clinical trial aims to evaluate the efficacy of non-invasive brain stimulation as an add-on treatment to standard detoxification therapy in patients with chronic migraine and medication overuse. The study also seeks to identify sensory and biochemical biomarkers predictive of treatment response.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07442916
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Chronic Migraine
Currently open trials in the same condition.
- NCT06974617 — Sphenopalatine Block Versus BOTOX in Management of Chronic Migraine · NA · recruiting
- NCT06684249 — Efficacy of Nerve Block Versus Botox in Chronic Migraine Management · NA · recruiting
- NCT05337033 — Cannabis for Chronic Headaches in Adolescents: the CAN-CHA Trial · Phase 2 · recruiting
- NCT06625060 — A Study to Evaluate IPN10200 Safety and Efficacy in the Prevention of Episodic or Chronic Migraine in Adults · Phase 2 · recruiting
- NCT06450444 — The RECLAIM Study. · NA · recruiting
Other IRCCS National Neurological Institute "C. Mondino" Foundation trials
Trials by the same sponsor.
- NCT06820411 — A Pilot Study to Assess Optimal Prevention and Outcome Improvement in Young Ischemic Stroke · NA · active not recruiting
- NCT06983119 — Case-Finding for Neurocognitive Disorders in Pavia · NA · recruiting
- NCT06453863 — Effects of Biofeedback Footwear in Parkinson's Disease: Assessment of Functional Motor Abilities and Locomotion · NA · not yet recruiting
- NCT06715436 — Multiple Sclerosis and the Effects of Ketogenic Diet Therapy · NA · recruiting
- NCT06262152 — Sleep Profile of Patients With Septo-optic Dysplasia · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07442916 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by IRCCS National Neurological Institute "C. Mondino" Foundation
- Last refreshed: 2 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07442916.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing