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NCT04908033
Ultra-high-frequency ECG for Prediction of Left Ventricular Remodeling
trial testing pacemaker implantation in RV Pacing in 368 participants. Status unknown.
1 June 2025
Quick facts
| Lead sponsor | Faculty Hospital Kralovske Vinohrady |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 368 |
| Start date | 1 May 2021 |
| Primary completion | 1 June 2025 |
| Estimated completion | 1 December 2025 |
| Sites | 1 location across Czechia |
Drugs / interventions tested
- pacemaker implantation
Conditions studied
- RV Pacing — all drugs for RV Pacing →
- Negative Remodeling — all drugs for Negative Remodeling →
- Dyssynchrony — all drugs for Dyssynchrony →
- UHF-ECG — all drugs for UHF-ECG →
Sponsor
Faculty Hospital Kralovske Vinohrady
Who can join
18 and older, any sex, with RV Pacing or Negative Remodeling. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The main goal of the project is to prove that ultra-high-frequency ECG (UHF-ECG) can be used as a diagnostic tool that allows the prediction of patients susceptible to the negative effect of right ventricular myocardial pacing. The prediction will be based on the assessment of electrical dyssynchrony and local depolarization durations of left ventricular depolarization emerging during right ventricular pacing. If proved to be valid in left ventricular negative remodeling prediction, UHF-ECG-derived parameters of ventricular dyssynchrony could be used as markers allowing a lead placement optimization during an implant procedure. This information can help the operator to identify patients with the urgent need for physiological pacing (HB or LBBp) and patients in which a right ventricular myocardial pacing is sufficient and will not lead to the development of the negative left ventricular remodeling.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Ventricular Dyssynchrony and Pacing-induced Cardiomyopathy in Patients with Pacemakers, the Utility of Ultra-high-frequency ECG and Other Dyssynchrony Assessment Tools.
Mizner J, Jurak P, Linkova H, Smisek R, et al · · 2022 · cited 12× · PMID 35990106 · DOI 10.15420/aer.2022.01
Verify or expand the search:
- PubMed search for NCT04908033
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Related trials
Other trials of pacemaker implantation
Trials testing the same drug.
- NCT06833138 — Atrioventricular Node Ablation and Conduction System Pacing in Patients With Well Controlled Permanent Atrial Fibrillati · NA · recruiting
Other Faculty Hospital Kralovske Vinohrady trials
Trials by the same sponsor.
- NCT07098520 — Biomarkers of Steatohepatitis in Type 2 Diabetes Patients · not yet recruiting
- NCT06803979 — Impact of Delivery Method Elite Athletes. · recruiting
- NCT07057544 — UHF ECG in LBBB and Response to CRT Prediction · NA · recruiting
- NCT06670716 — BRIEF COGNITIVE and DELIRIUM ASSESSMENTS in STROKE PATIENTS · active not recruiting
- NCT06016712 — The Effect of Labor on Intraocular Pressure Fluctuation in Healthy Eyes · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04908033 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Faculty Hospital Kralovske Vinohrady
- Last refreshed: 5 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04908033.
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