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NCT07057544: UHF BLOCK
UHF ECG in LBBB and Response to CRT Prediction
NA trial testing LBBAP CRT device implantation in Left Bundle Branch Block in 200 participants. Currently enrolling.
31 December 2027
Quick facts
| Lead sponsor | Faculty Hospital Kralovske Vinohrady |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 200 |
| Start date | 1 May 2024 |
| Primary completion | 31 December 2027 |
| Estimated completion | 31 December 2027 |
| Sites | 1 location across Czechia |
Drugs / interventions tested
- LBBAP CRT device implantation
- BVP-CRT
Conditions studied
- Left Bundle Branch Block — all drugs for Left Bundle Branch Block →
- Left Bundle Branch Area Pacing — all drugs for Left Bundle Branch Area Pacing →
- Biventricular Pacing — all drugs for Biventricular Pacing →
- Intraventricular Conduction Delay — all drugs for Intraventricular Conduction Delay →
Sponsor
Faculty Hospital Kralovske Vinohrady
Who can join
18 and older, any sex, with Left Bundle Branch Block or Left Bundle Branch Area Pacing. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The main objective of the project is to demonstrate that in patients with heart failure and QRS complex of nonRBBB morphology lasting over 130 ms, UHF-ECG can differentiate patients with trueLBBB from IVCD better than existing approaches based on the assessment of QRS complex morphology and duration from 12-lead ECG. Another goal of the proposed study is to demonstrate that trueLBBB patients will benefit more from CRT using left bundle branch pacing than from CRT using biventricular pacing. The final aim of the project is to demonstrate that the echocardiographic and clinical response in patients with intraventricular conduction disturbance will be dependent on the degree of reduction in ventricular dyssynchrony after CRT.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07057544
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07057544 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Faculty Hospital Kralovske Vinohrady
- Last refreshed: 14 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07057544.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing