Who is sponsoring NCT04904679?

NCT04904679 is sponsored by Hospital Oftalmologico de Sorocaba.

What drugs are being tested in NCT04904679?

Interventions in NCT04904679: Pars plana Vitrectomy with internal limiting membrane peeling.

What condition does NCT04904679 study?

NCT04904679 studies Macular Holes.

Is NCT04904679 still recruiting?

NCT04904679 is currently active, enrolled. Last updated 6 May 2025.

Last reviewed 2025-05-06 · How we verify

NCT04904679

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Use of Amniotic Membrane or Internal Limiting Membrane for Large or Refractory Macular Holes: A Prospective Study

Active, enrolled NA Last updated 6 May 2025

What this trial tests

NA trial testing Pars plana Vitrectomy with internal limiting membrane peeling in Macular Holes in 23 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

26 June 2020

Primary endpoint
30 September 2023

31 December 2025

Quick facts

Lead sponsor	Hospital Oftalmologico de Sorocaba
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	23
Start date	26 June 2020
Primary completion	30 September 2023
Estimated completion	31 December 2025
Sites	2 locations across Brazil

Drugs / interventions tested

Pars plana Vitrectomy with internal limiting membrane peeling

Conditions studied

Macular Holes — all drugs for Macular Holes →

Sponsor

Hospital Oftalmologico de Sorocaba

Who can join

18 and older, any sex, with Macular Holes. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Prospective, randomized, unmasked interventional study. To evaluate anatomical and functional results through microperimetry in cases of refractory or large macular holes (MH), using amniotic membrane (AM) or internal limiting membrane ( ILM ).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

The use of amniotic membrane or inverted internal limiting membrane flap for large or refractory macular holes: a prospective, comparative study using microperimetry.
Carvalho Araujo AC, Bordon AF, Falcão V, Bortolai P, et al · · 2025 · PMID 40952489 · DOI 10.1007/s00417-025-06917-3

Verify or expand the search:

Other recruiting trials for Macular Holes

Currently open trials in the same condition.

NCT06211907 — Small Macular Holes Treated With Air · NA · recruiting
NCT06000111 — Duration of Face Down Positioning for Full-Thickness Macular Hole Repair · NA · recruiting
NCT03713268 — Intraoperative OCT Guidance of Intraocular Surgery II · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04904679 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hospital Oftalmologico de Sorocaba
Last refreshed: 6 May 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04904679.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing