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NCT04894500: ICARUS
ICIS in Burn Patients Compared to Other Inflammatory Markers
trial testing Flow fluorescence cytometry in Infection, Bacterial in 97 participants. Completed in 31 October 2024.
30 June 2024
Quick facts
| Lead sponsor | Charles University, Czech Republic |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 97 |
| Start date | 1 April 2021 |
| Primary completion | 30 June 2024 |
| Estimated completion | 31 October 2024 |
| Sites | 1 location across Czechia |
Drugs / interventions tested
- Flow fluorescence cytometry
Conditions studied
- Infection, Bacterial — all drugs for Infection, Bacterial →
- Burns — all drugs for Burns →
- Inflammation — all drugs for Inflammation →
Sponsor
Charles University, Czech Republic
Who can join
Adults 6 Months to 100, any sex, with Infection, Bacterial or Burns. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The current markers of inflammation that govern antibiotic treatment have their significant limitations, especially in patients with burns. According to previously published data, the newly proposed marker of infectious inflammation, the Intensive Care Infection Score (ICIS), appears to be a suitable diagnostic tool in distinguishing between inflammation of infectious and non-infectious origin in these patients. The other advantage is its low price. This study aims to compare ICIS with other used indicators of inflammation in patients with burns both children and adults.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Early identification of infectious complications in pediatric burn patients: a prospective cohort study.
Bakalář B, Zajíček R, Frejlach D, Adámková V, et al · · 2026 · PMID 42002740 · DOI 10.1186/s12887-026-06867-7
Verify or expand the search:
- PubMed search for NCT04894500
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Charles University, Czech Republic trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04894500 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Charles University, Czech Republic
- Last refreshed: 7 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04894500.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing