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NCT04882020
Inflammation and Neurocognitive Damage Markers in Elderly People With Obstructive Sleep Apnea
trial testing cortisol, BDNF, s100B, IL-1B, IL-6, IL-10, TNF-alpha in Obstructive Sleep Apnea in 76 participants. Status unknown.
30 April 2021
Quick facts
| Lead sponsor | Hospital de Clinicas de Porto Alegre |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 76 |
| Start date | 21 August 2019 |
| Primary completion | 30 April 2021 |
| Estimated completion | 11 June 2021 |
| Sites | 1 location across Brazil |
Drugs / interventions tested
- cortisol, BDNF, s100B, IL-1B, IL-6, IL-10, TNF-alpha
Conditions studied
- Obstructive Sleep Apnea — all drugs for Obstructive Sleep Apnea →
- Sleep Apnea — all drugs for Sleep Apnea →
- Apnea, Obstructive — all drugs for Apnea, Obstructive →
- Obstructive Sleep Apnea Syndrome — all drugs for Obstructive Sleep Apnea Syndrome →
Sponsor
Hospital de Clinicas de Porto Alegre
Who can join
Adults 65 to 80, any sex, with Obstructive Sleep Apnea or Sleep Apnea. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aging process tends to promote an overall increase in inflammation compromising the immunologic system regulation, sleep/wakefulness pattern, and neurocognitive performance. In elders, there is an increase in repetitive arousals during sleep, secondary to breathing interruption by pharynx collapse, generating a transient reduction in oxygen delivery to the brain known as obstructive sleep apnea. This lack in oxygen supply results in an inflammatory process producing brain damage. Some substances present in the blood seem to be associated to neurocognitive damage, like S100β protein, cortisol, interleukin 1-β,6 and TNF-α. In the other way, a substance called brain-derived neurotrophic factor (BDNF) enhances cognitive function, and memory consolidation improvement.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04882020
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Obstructive Sleep Apnea
Currently open trials in the same condition.
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- NCT07447011 — Glaucoma Respsosne to Lifestyle Corrections in Sleep Apnea · NA · recruiting
- NCT07397780 — RPMO2 Oximeter Accuracy During Sleep 1 Trial · active not recruiting
- NCT06698809 — Obstructive Sleep Apnea Therapeutic Intervention for REsiDual Sleepiness · NA · recruiting
Other Hospital de Clinicas de Porto Alegre trials
Trials by the same sponsor.
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- NCT07052058 — Triple-Blind Randomized Clinical Trial of Tocilizumab vs Placebo: Potential Use of an IL-6 Antagonist as an Adjuvant to · Phase 2 · not yet recruiting
- NCT06953128 — General Versus Regional Anesthesia in Peripheral Arterial Surgery · NA · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04882020 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital de Clinicas de Porto Alegre
- Last refreshed: 11 May 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04882020.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing