NCT04877210 is a Phase 1 clinical trial of Topical Insulin in Dry Eye, sponsored by Universiti Kebangsaan Malaysia Medical Centre.

Who is sponsoring NCT04877210?

NCT04877210 is sponsored by Universiti Kebangsaan Malaysia Medical Centre.

What drugs are being tested in NCT04877210?

Interventions in NCT04877210: Topical Insulin.

Is NCT04877210 still recruiting?

NCT04877210 is currently status unknown. Last updated 11 May 2021.

Last reviewed 2021-05-11 · How we verify

NCT04877210

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effects of Topical Insulin on Levels of Tear Inflammatory Mediators

Status unknown Phase 1 Last updated 11 May 2021

What this trial tests

Phase 1 trial testing Topical Insulin in Dry Eye in 60 participants. Status unknown.

Timeline

22 October 2020

Primary endpoint
1 August 2021

26 January 2022

Quick facts

Lead sponsor	Universiti Kebangsaan Malaysia Medical Centre
Phase	Phase 1
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	single group
Masking	double
Primary purpose	treatment
Enrollment	60
Start date	22 October 2020
Primary completion	1 August 2021
Estimated completion	26 January 2022
Sites	1 location across Malaysia

Drugs / interventions tested

Topical Insulin — full drug profile →

Conditions studied

Dry Eye — all drugs for Dry Eye →

Sponsor

Universiti Kebangsaan Malaysia Medical Centre — full company profile →

Who can join

Adults 18 to 50, any sex, with Dry Eye. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

60 samples are take to determine the effects of topical insulin on tear inflammatory mediators interleukin 1a, interleukin 6 and matrix metalloprotenase 9 in diabetics with dry eye disease.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Dry eye syndrome: comprehensive etiologies and recent clinical trials.
Huang R, Su C, Fang L, Lu J, et al · · 2022 · cited 52× · PMID 35678897 · DOI 10.1007/s10792-022-02320-7

Verify or expand the search:

Other recruiting trials for Dry Eye

Currently open trials in the same condition.

NCT07366944 — PCOS and Problem of Eye Dryness: Is There a Benefit From Lifetyle Changes · NA · recruiting
NCT07329712 — Comparing Tear Proteomics Profile in Dry Eye Disease pre-and Post-treatment With Low Level Light Therapy · recruiting
NCT07266948 — Impact of TRYPTYR on a Patient's Quality of Life and Ability to Perform Work · Phase 4 · recruiting
NCT07298811 — Preliminary Clinical Study of the Effectiveness and Safety of Ocular Surface Microbiota Transplantation in the Treatment · Phase 1, PHASE2 · recruiting
NCT07135193 — Evaluation of the Protective Effects of Cordyceps Cicadae on Visual Function and Anti-Fatigue Performance in Esports Ath · NA · active not recruiting

Other Universiti Kebangsaan Malaysia Medical Centre trials

Trials by the same sponsor.

NCT07466485 — The Efficacy of Tocotrienol Rich Fraction for Liver Protection in Adult Patients With Alcoholic Fatty Liver Disease (AFL · Phase 2 · recruiting
NCT07041814 — A Study Comparing Different Treatment Approaches for the Initiation of Puberty in Girls With Turner Syndrome Using a TRI · Phase 2 · not yet recruiting
NCT07000227 — Mechanism of FODMAP Restriction on FGID Patients · NA · recruiting
NCT05694858 — Transdermal Microneedle Lignocaine Delivery Versus EMLA Patch for Topical Analgesia Before Venepuncture Procedure To Adu · Phase 1, PHASE2 · recruiting
NCT07447310 — Comparing 360-degree VR Video of Local vs Overseas Environment on Psychological Health · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04877210 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Universiti Kebangsaan Malaysia Medical Centre
Last refreshed: 11 May 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04877210.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing