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NCT04875364: ExPRESSION
Do Endotypes Predict Response and Sequelae in OSA Patients
Phase 2 trial testing Eszopiclone in Obstructive Sleep Apnea in 200 participants. Currently enrolling.
1 January 2027
Quick facts
| Lead sponsor | University of California, San Diego |
|---|---|
| Phase | Phase 2 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 200 |
| Start date | 1 August 2020 |
| Primary completion | 1 January 2027 |
| Estimated completion | 1 January 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Eszopiclone (ESZOPICLONE) — full drug profile →
- Supplemental Oxygen — full drug profile →
- Continuous Positive Airway Pressure (CPAP)
Conditions studied
- Obstructive Sleep Apnea — all drugs for Obstructive Sleep Apnea →
- Sleep Apnea — all drugs for Sleep Apnea →
- Sleep Apnea, Obstructive — all drugs for Sleep Apnea, Obstructive →
- Sleep — all drugs for Sleep →
Sponsor
University of California, San Diego
Who can join
Adults 21 to 65, any sex, with Obstructive Sleep Apnea or Sleep Apnea. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study will investigate why some people have Obstructive Sleep Apnea (OSA) and how the underlying cause may relate to OSA manifestations (including sleepiness and high blood pressure) and response to different therapeutic approaches (ie CPAP, eszopiclone, and supplemental oxygen). Understanding why someone has OSA could affect how best to treat that individual, but may also have an impact on what problems the disease might cause.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04875364
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Eszopiclone
Trials testing the same drug.
- NCT03668041 — National Adaptive Trial for PTSD Related Insomnia · Phase 3 · completed
- NCT04639193 — Combination Drug-Therapy for Patients With Untreated Obstructive Sleep Apnea · Phase 2 · completed
- NCT02456532 — Safety and Efficacy of Chronic Hypnotic Use 2 · Phase 4 · completed
- NCT02452684 — Investigation of the Safety and Efficacy of Eszopiclone in Insomnia Patients · completed
- NCT02455271 — Investigation of the Safety and Efficacy of Long Term Administration of Eszopiclone in Insomnia Patients · completed
Other recruiting trials for Obstructive Sleep Apnea
Currently open trials in the same condition.
- NCT07195253 — Oro-myofunctional Characteristics and Obstructive Sleep Apnea in Infants With Down Syndrome · recruiting
- NCT07273019 — Tongue Muscular Assessment in Children With Sleep Disordered Breathing · NA · recruiting
- NCT07447011 — Glaucoma Respsosne to Lifestyle Corrections in Sleep Apnea · NA · recruiting
- NCT07397780 — RPMO2 Oximeter Accuracy During Sleep 1 Trial · active not recruiting
- NCT06698809 — Obstructive Sleep Apnea Therapeutic Intervention for REsiDual Sleepiness · NA · recruiting
Other University of California, San Diego trials
Trials by the same sponsor.
- NCT07342543 — Guided Physical Activity Counseling for Hypertension in Primary Care · NA · not yet recruiting
- NCT06505317 — Artificial Intelligence for Early Detection of Peripheral Artery Disease · NA · not yet recruiting
- NCT07211802 — CKM For Safe Use of SGLT2i in Type 1 Diabetes · Phase 3 · not yet recruiting
- NCT07524751 — Culturally Adapted Pain Management for Indigenous Peoples · NA · not yet recruiting
- NCT07518784 — Accurate Point of Care Liver Disease Diagnostics (Phase 2) · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04875364 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of California, San Diego
- Last refreshed: 2 October 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04875364.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing