NCT04867655

Acute Effect of Orange Juice Mixed With Oat β-Glucan on Bioavailability of Polyphenols in Healthy Individuals

Status unknown NA Last updated 2 November 2021

What this trial tests

NA trial testing Orange Juice in Healthy in 16 participants. Status unknown.

Timeline

10 July 2019

Primary endpoint
4 May 2022

4 May 2022

Quick facts

Lead sponsor	University of Glasgow
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	other
Enrollment	16
Start date	10 July 2019
Primary completion	4 May 2022
Estimated completion	4 May 2022
Sites	1 location across United Kingdom

Drugs / interventions tested

• Orange Juice — full drug profile →
• Orange juice with either 6g or 3 g of β-Glucan

Conditions studied

• Healthy — all drugs for Healthy →

Sponsor

University of Glasgow

Who can join

Adults 18 to 50, any sex, with Healthy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Brief summary Orange juice is the most widely consumed fruit juice, accounting for around a third of the total fruit juice market and is a rich source of vitamin C and bioactive compounds, predominantly flavonoids. Current research into the health effects of fruit juice consumption has presented some conflicting conclusions. Although potential health benefits have been attributed to the anti-inflammatory and anti-oxidant properties of the bioactive components in juice, other studies have suggested that the benefits of consuming orange are outweighed by the negative implications of the high sugar content leading to increases in blood glucose and insulin. At the same time it is well established that supplementation with a mean dose of 5g of β-Glucan, a soluble fibre derived from cereals such as oats or barley, significantly reduces insulin and glucose in healthy subjects and metabolic compromised individuals. Thus, the formulation of an OJ beverage with an added β-Glucan supplement may be a useful strategy to attenuate the detrimental impact of high sugar content. However, while delaying the absorption of glucose brings about favourable effects on post-prandial glycemia, dietary fibre may also reduce the bioavailability of some beneficial compounds, including polyphenols. So far, it remains unclear how addition of β-Glucan impacts bioavailability of orange juice flavanones. Thus, this study aims to determine how the bioavailability of orange juice polyphenols of healthy adults is affected mixing orange juice with 3 g and 6 g of oat β-Glucan.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. A Scoping Review of the Skeletal Effects of Naringenin.
   Nor Muhamad ML, Ekeuku SO, Wong SK, Chin KY. · · 2022 · cited 16× · PMID 36432535 · DOI 10.3390/nu14224851
2. Bioavailability of orange juice (poly)phenols: β-glucan-rich oat bran decreases urinary excretion of flavanone phase II metabolites and enhances excretion of microbiota-derived phenolic catabolites.
   Pereira-Caro G, Almutairi TM, Cáceres-Jiménez S, Moreno-Rojas JM, et al · · 2023 · cited 5× · PMID 36764628 · DOI 10.1016/j.freeradbiomed.2023.02.002