NCT03806829

The Acute Effects of Commercially Available Drinks on the Endothelial Function of Humans Following a High-fat Meal

Completed NA Last updated 16 January 2019

What this trial tests

NA trial testing Water in Endothelial Dysfunction in 7 participants. Completed in 31 July 2018.

Timeline

6 June 2018

Primary endpoint
31 July 2018

31 July 2018

Quick facts

Lead sponsor	University of the Highlands and Islands
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	prevention
Enrollment	7
Start date	6 June 2018
Primary completion	31 July 2018
Estimated completion	31 July 2018
Sites	1 location across United Kingdom

Drugs / interventions tested

• Water (WATER) — full drug profile →
• Red Wine
• Green Tea — full drug profile →
• Orange Juice — full drug profile →

Conditions studied

• Endothelial Dysfunction — all drugs for Endothelial Dysfunction →

Sponsor

University of the Highlands and Islands

Who can join

Adults 50 to 65, any sex, with Endothelial Dysfunction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

High fat diets are associated with impaired endothelial function and increased cardiovascular disease risk amongst our population. These negative effects are likely caused by triglyceride induced suppression of nitric oxide, which is produced from the endothelium, and/or an increase in oxidative stress.

Interestingly, previous studies have found that some beverages that are high in polyphenols and antioxidants may suppress the impairment in endothelial function observed following high fat meals/diets. Typically, these studies have investigated the ingestion of red wine, orange juice or green tea on outcome measures (typically flow mediated dilatation (FMD) of the brachial artery). Despite this previous research, no study has compared the effects of different beverages on endothelial outcomes following a high-fat meal within the same participants.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Co-ingestion of Antioxidant Drinks With an Unhealthy Challenge Meal Fails to Prevent Post-prandial Endothelial Dysfunction: An Open-Label, Crossover Study in Older Overweight Volunteers.
   Muggeridge DJ, Goszcz K, Treweeke A, Adamson J, et al · · 2019 · cited 3× · PMID 31681007 · DOI 10.3389/fphys.2019.01293