NCT04867317 (GRIT) is a Phase 3 clinical trial of Somatropin in Adult Growth Hormone Deficiency, sponsored by VA Office of Research and Development.

Who is sponsoring NCT04867317?

NCT04867317 is sponsored by VA Office of Research and Development.

What drugs are being tested in NCT04867317?

Interventions in NCT04867317: Somatropin, Placebo.

What condition does NCT04867317 study?

NCT04867317 studies Adult Growth Hormone Deficiency, Mild Traumatic Brain Injury.

Is NCT04867317 still recruiting?

NCT04867317 is currently recruiting now. Last updated 9 April 2026.

Last reviewed 2026-04-09 · How we verify

NCT04867317: GRIT

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD)

Recruiting now Phase 3 Last updated 9 April 2026

What this trial tests

Phase 3 trial testing Somatropin in Adult Growth Hormone Deficiency in 172 participants. Currently enrolling.

Timeline

13 January 2025

Primary endpoint
28 February 2027

30 September 2029

Quick facts

Lead sponsor	VA Office of Research and Development
Phase	Phase 3
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	172
Start date	13 January 2025
Primary completion	28 February 2027
Estimated completion	30 September 2029
Sites	4 locations across United States

Drugs / interventions tested

Somatropin (Somatropin) — full drug profile →
Placebo

Conditions studied

Adult Growth Hormone Deficiency — all drugs for Adult Growth Hormone Deficiency →
Mild Traumatic Brain Injury — all drugs for Mild Traumatic Brain Injury →

Sponsor

VA Office of Research and Development — full company profile →

Who can join

Adults 21 to 55, any sex, with Adult Growth Hormone Deficiency or Mild Traumatic Brain Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to determine whether growth hormone replacement therapy (GHRT) is effective versus placebo in the improvement of Quality of Life in patients with adult growth hormone deficiency (AGHD) and mild traumatic brain injury (mTBI).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Current Clinical Trials in Traumatic Brain Injury.
Ahmed Z. · · 2022 · cited 23× · PMID 35624914 · DOI 10.3390/brainsci12050527

Verify or expand the search:

Other trials of Somatropin

Trials testing the same drug.

NCT06103513 — Randomized Clinical Trial of Two Different Initial Growth Hormone Doses in Children · Phase 3 · unknown
NCT05900661 — The Effect of Myo-inositol, Somatropin, and DHEA on Poor Ovarian Responders · Phase 2, PHASE3 · unknown
NCT05382637 — Growth Hormone in a Patient With a Dominant-Negative GHR Mutation · Phase 2 · active not recruiting
NCT04615273 — A Trial to Compare the Efficacy and Safety of Once-weekly Lonapegsomatropin With Placebo and a Daily Somatropin Product · Phase 3 · completed
NCT02597660 — A Study to Evaluate the Efficacy of Somatropin in the Treatment of Patellar Tendinopathy · Phase 2 · withdrawn

Other recruiting trials for Adult Growth Hormone Deficiency

Currently open trials in the same condition.

NCT07016802 — A Clinical Study of GenSci134 in Healthy Adults and Adult Growth Hormone Deficiency(AGHD) · Phase 1 · recruiting
NCT05230550 — Post-Marketing Surveillance (Special Use-results Surveillance on Long-term Use) With Sogroya® · active not recruiting

Other VA Office of Research and Development trials

Trials by the same sponsor.

NCT07456150 — Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care · Phase 1 · not yet recruiting
NCT06746727 — The Development of a Transdiagnostic Intervention to Improve Social Functioning and Intimate Relationships Among Veteran · NA · not yet recruiting
NCT07362576 — Perinatal Peer Support for Veterans With Serious Mental Illness · NA · not yet recruiting
NCT06766331 — Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans · NA · not yet recruiting
NCT07397195 — ACT for Veterans With IBD and Mental Health Challenges · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04867317 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by VA Office of Research and Development
Last refreshed: 9 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04867317.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing