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NCT04844775: EHVA P01
A Prophylactic HIV Vaccine Trial to Evaluate the Safety and Immunogenicity of HIV Clade C DREP Alone and in Combination With a Clade C ENV Protein in Healthy HIV-uninfected Adults
Phase 1 trial testing Drep-HIV-PT1 0.2mg and CN54gp140/MPLA-L in Healthy Adults in 68 participants. Completed in 9 September 2024.
9 September 2024
Quick facts
| Lead sponsor | ANRS, Emerging Infectious Diseases |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 68 |
| Start date | 5 August 2022 |
| Primary completion | 9 September 2024 |
| Estimated completion | 9 September 2024 |
| Sites | 4 locations across France, United Kingdom, Switzerland |
Drugs / interventions tested
- Drep-HIV-PT1 0.2mg and CN54gp140/MPLA-L — full drug profile →
- DREP-HIV-PT1 1mg and CN54gp140/MPLA-L (see above) — full drug profile →
- DNA-HIV-PT123 4mg and CN54gp140/MPLA-L — full drug profile →
Conditions studied
- Healthy Adults — all drugs for Healthy Adults →
Sponsor
ANRS, Emerging Infectious Diseases — full company profile →
Who can join
Adults 18 to 55, any sex, with Healthy Adults. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
EHVA P01 is an international, phase I, prophylactic HIV vaccine trial to evaluate the safety and immunogenicity of HIV Clade C DREP alone and in Combination with a Clade C ENV protein in healthy HIV-uninfected adults.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Recent advances in HIV-1 envelope-based vaccine designs for guiding broadly neutralizing antibody response.
Singh S, Kumar S, Luthra K. · · 2026 · PMID 42012184 · DOI 10.1128/jvi.02202-25
Verify or expand the search:
- PubMed search for NCT04844775
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other ANRS, Emerging Infectious Diseases trials
Trials by the same sponsor.
- NCT07098481 — Access to Hepatitis C Treatment in Cameroon: Comparison of a Simplified Test and Treat Strategy to a Standard Strategy · Phase 4 · not yet recruiting
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- NCT07113106 — Dose Escalation Trial of CD40.Pan.CoV Vaccine, Adjuvanted or Not, as a Booster in Adult Healthy Volunteers · Phase 1, PHASE2 · recruiting
- NCT05222945 — A Study to Determine the Cartography of Virologic Reservoir Related to Antiretroviral Concentrations in HIV-1 Chronic Pa · NA · not yet recruiting
- NCT06522256 — Identification of Molecular Signatures of High-risk Oncogenic HPV and Study of Their Associations With the Presence of H · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04844775 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by ANRS, Emerging Infectious Diseases
- Last refreshed: 9 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04844775.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing