Last reviewed · How we verify
NCT04815278: NCW4H
NC Works4Health: Reducing Chronic Disease Risks in Socioeconomically Disadvantaged, Unemployed Populations
NA trial testing Immediate Chronic Disease Prevention Program (CDPP) in Diabetes in 455 participants. Completed in 30 November 2025.
30 November 2025
Quick facts
| Lead sponsor | University of North Carolina, Chapel Hill |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | factorial |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 455 |
| Start date | 17 September 2021 |
| Primary completion | 30 November 2025 |
| Estimated completion | 30 November 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Immediate Chronic Disease Prevention Program (CDPP)
- Workplace Equity, Job and Health Supports Employer Intervention
- Delayed, attenuated Chronic Disease Prevention Program (CDPP)
Conditions studied
- Diabetes — all drugs for Diabetes →
- Chronic Disease — all drugs for Chronic Disease →
- Psychological Distress — all drugs for Psychological Distress →
Sponsor
University of North Carolina, Chapel Hill
Who can join
Adults 18 to 64, any sex, with Diabetes or Chronic Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The proposed study, NC Works4Health (NCW4H), builds on the strengths of long-standing academic-community research partnerships between this UNC at Chapel Hill (UNC) team of investigators and key stakeholders across health, social service, employment, and economic development sectors. The overall goal of this study is to test the effectiveness of a multilevel intervention that can be readily adopted by communities to reduce chronic disease risks in socioeconomically disadvantaged populations by (a) embedding prevention efforts in DSS-E programs at the individual level, and (b) enhancing supervisor supports for DSS-E hires at the employer level. Interventions at each level, and their joint effects, are designed to mitigate the psychological, behavioral, and clinically relevant risks for chronic disease onset, morbidity, and comorbidity that accrue with unemployment and the employment-entry transition.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
A Multilevel Intervention to Reduce Chronic Disease Risk in Socioeconomically Disadvantaged Unemployed Populations: The<i>North Carolina Works 4 Health (NCW4H)</i>Clinical Trial Protocol
Kneipp SM. · · 2024 · DOI 10.1101/2024.01.11.24301167
Verify or expand the search:
- PubMed search for NCT04815278
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04815278 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of North Carolina, Chapel Hill
- Last refreshed: 2 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04815278.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing