NCT04813900: O2LUSS

Correlation Between Lung UltraSound Score and Hypoxemia for Interstitial Syndrome in Emergency Department

Completed NA Last updated 19 January 2022

What this trial tests

NA trial testing Lung ultrasound in Interstitial Lung Disease in 162 participants. Completed in 30 August 2021.

Timeline

1 April 2021

Primary endpoint
30 August 2021

30 August 2021

Quick facts

Lead sponsor	Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	other
Enrollment	162
Start date	1 April 2021
Primary completion	30 August 2021
Estimated completion	30 August 2021
Sites	1 location across Belgium

Drugs / interventions tested

• Lung ultrasound

Conditions studied

• Interstitial Lung Disease — all drugs for Interstitial Lung Disease →

Sponsor

Cliniques universitaires Saint-Luc- Université Catholique de Louvain — full company profile →

Who can join

18 and older, any sex, with Interstitial Lung Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The primary objective of this study is to assess the presence of a correlation between the Lung ultrasound score (LUSS) and PaO2/FiO2 in patient presenting with interstitial syndrome (IS) in the ED. The primary end point considers the null hypothesis to be a negative linear distribution for LUSS and PaO2/FiO2 values.

Secondary objectives and secondary end points One of the secondary objectives is to assess the correlation between the LUSS and PaCO2 in patient presenting with IS in the ED. The end point of this secondary outcome considers the null hypothesis to be a positive linear distribution for the LUSS and PaCO2 values.

Another secondary objective is to determine the influence of the presence of unilateral or bilateral pleural effusion on the correlation between LUSS and PaO2/FiO2. The end point of this secondary outcome considers the null hypothesis to be a negative linear distribution for LUSS and PaO2/FiO in those three sub-groups: absence of pleural effusion group, unilateral pleural effusion group and bilateral pleural effusion group.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Correlation between hypoxaemia and lung ultrasound score in patients presenting to an emergency department with interstitial syndrome: a prospective physiological study.
   Vasseur E, Moureau G, Fasseaux A, Peyskens L, et al · · 2022 · PMID 38046212 · DOI 10.51893/2022.3.oa2