Last reviewed · How we verify
NCT04811014: YHEROES
Young Houston Emergency Opioid Engagement System
Phase 4 trial testing Buprenorphine, Naloxone Drug Combination in Opioid-use Disorder in 250 participants. Currently enrolling.
31 August 2030
Quick facts
| Lead sponsor | The University of Texas Health Science Center, Houston |
|---|---|
| Phase | Phase 4 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 250 |
| Start date | 19 April 2021 |
| Primary completion | 31 August 2030 |
| Estimated completion | 31 August 2030 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Buprenorphine, Naloxone Drug Combination — full drug profile →
- Individual Counseling
- Peer Recovery Support Services
- Support Group
- Referral to Medication Management
- Assertive Outreach
Conditions studied
- Opioid-use Disorder — all drugs for Opioid-use Disorder →
- Opioid Dependence — all drugs for Opioid Dependence →
- Opioid Overdose — all drugs for Opioid Overdose →
- Opioid Use — all drugs for Opioid Use →
Sponsor
The University of Texas Health Science Center, Houston
Who can join
Adults 13 to 17, any sex, with Opioid-use Disorder or Opioid Dependence. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The Houston Emergency Response Opioid Engagement System for Youths and Adolescents (Young HEROES) is a community-based research program integrating assertive outreach, medication for opioid use disorder (MOUD), behavioral counseling, and peer recovery support. The objective is to compare differences in engagement and retention in treatment for individuals with opioid use disorder. The investigators also intend to understand the prevalence of opioid overdoses and OUD among youth in Houston.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04811014
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other The University of Texas Health Science Center, Houston trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04811014 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The University of Texas Health Science Center, Houston
- Last refreshed: 1 October 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04811014.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing