Last reviewed 2026-04-19 · How we verify

Opioid dependence

6 treatments

Approved treatments

Methadyl
Methadyl works by blocking potassium channels in the brain to stabilize neuronal activity and reduce withdrawal symptoms.
Subutex · Indivior
Buprenorphine is a partial agonist at mu-opioid receptors and antagonist at kappa-opioid receptors.
Narcan · Adapt
LEVOMETHADONE
LEVOMETHADONE works by binding to opioid receptors in the brain, reducing withdrawal symptoms and cravings.
Subutex · Purdue Pharma Lp
Buprenorphine binds to mu-opioid receptors as a partial agonist and kappa-opioid receptors as an antagonist.
Orlaam · Roxane

Clinical guidelines

FDA label — 1L
Buprenorphine sublingual tablets is indicated for the treatment of opioid dependence and is preferred for induction.

Competitive intelligence

For the full treatment-landscape CI brief — marketed leaders side-by-side, pipeline by phase, recent regulatory actions, sponsor landscape:

Opioid dependence patent landscape — cliff calendar, originator estates, attackable patents
Opioid dependence treatment landscape brief
Opioid dependence treatment updates RSS

Frequently asked questions about Opioid dependence

What drugs treat Opioid dependence?

Tracked treatments include Methadyl, Subutex, Narcan, LEVOMETHADONE, Orlaam.

What is the treatment for Opioid dependence?

Standard treatment for Opioid dependence includes Methadyl, Subutex, Narcan, LEVOMETHADONE, Orlaam. See the treatment landscape page for first-line, second-line and salvage options.

What are the treatment guidelines for Opioid dependence?

FDA label publishes guidelines for Opioid dependence. 1 guideline references tracked.

Treatment landscape: Opioid dependence patent cliff · Opioid dependence CI report
Treatment: Methadyl
Treatment: Subutex · Indivior
Treatment: Narcan · Adapt
Treatment: LEVOMETHADONE
Treatment: Subutex · Purdue Pharma Lp
All diseases: Browse the disease index · Disease landscape hub

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing