Who is sponsoring NCT04791137?

NCT04791137 is sponsored by Ruhr University of Bochum.

What drugs are being tested in NCT04791137?

Interventions in NCT04791137: Imagery cognitive bias modification.

What condition does NCT04791137 study?

NCT04791137 studies Anhedonia, Depression.

Is NCT04791137 still recruiting?

NCT04791137 is currently completed. Last updated 28 January 2022.

Last reviewed 2022-01-28 · How we verify

NCT04791137

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Feasibility Randomized Controlled Trial Using a 'Leapfrog' Design

Completed NA Last updated 28 January 2022

What this trial tests

NA trial testing Imagery cognitive bias modification in Anhedonia in 188 participants. Completed in 11 January 2022.

Timeline

9 April 2021

Primary endpoint
11 January 2022

11 January 2022

Quick facts

Lead sponsor	Ruhr University of Bochum
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	188
Start date	9 April 2021
Primary completion	11 January 2022
Estimated completion	11 January 2022
Sites	1 location across Germany

Drugs / interventions tested

Imagery cognitive bias modification

Conditions studied

Anhedonia — all drugs for Anhedonia →
Depression — all drugs for Depression →

Sponsor

Ruhr University of Bochum

Who can join

18 and older, any sex, with Anhedonia or Depression. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is a small-scale randomized controlled trial (RCT) using a 'Leapfrog' design (Blackwell, Woud, Margraf, \& Schönbrodt, 2019) with the aim of investigating feasibility of this design in the context of an RCT of an internet-delivered intervention. The leapfrog design will be applied to a simple cognitive training intervention, imagery cognitive bias modification (imagery CBM), completed over a four-week training period. The trial will start with the three arms described in the initial registration, but these will be removed and new arms added over the course of the trial on the basis of sequential Bayesian analyses.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Demonstration of a 'leapfrog' randomized controlled trial as a method to accelerate the development and optimization of psychological interventions.
Blackwell SE, Schönbrodt FD, Woud ML, Wannemüller A, et al · · 2023 · cited 12× · PMID 36330836 · DOI 10.1017/s0033291722003294
Demonstration of a ‘leapfrog’ randomized controlled trial as a method to accelerate the development and optimization of psychological interventions
Blackwell SE, Schönbrodt FD, Woud ML, Wannemüller A, et al · · 2022 · DOI 10.31234/osf.io/dvzn4

Verify or expand the search:

Other recruiting trials for Anhedonia

Currently open trials in the same condition.

NCT07493369 — Positive Affect Treatment for Spanish-Speaking Individuals · NA · active not recruiting
NCT07319143 — The Effect of Transcranial Direct Current Stimulation (tDCS) in Improving Emotion Health · NA · recruiting
NCT07490353 — Elucidating the Relevance of the Psychedelic Experience to Psilocybin's Anti-Anhedonic Effects · Phase 1 · recruiting
NCT06665620 — Optimizing a Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents · NA · active not recruiting
NCT06829953 — Get ActivE Study for At-risk Youth · NA · recruiting

Other Ruhr University of Bochum trials

Trials by the same sponsor.

NCT07432945 — In Vivo Exposure vs. Videochat-Based Vicarious Exposure · NA · recruiting
NCT06255821 — The Effect of Time on Generalization of Exposure-based Benefit · NA · completed
NCT05824884 — Self-efficacy Enhancement in a Virtual Reality Training for Fear of Heights · NA · recruiting
NCT05798078 — The Relationship Between Social Anxiety and Anxious Thinking Styles · NA · completed
NCT05780203 — CBM in the Context of Exposure for Acrophobia · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04791137 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ruhr University of Bochum
Last refreshed: 28 January 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04791137.

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