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NCT04785651
Evaluation of the Use of Tranexamic Acid in Tibial Osteotomies
NA trial testing Tibial osteotomy with Tranexamic acid in Monocompartimental Tibiofemoral Osteoarthritis in 49 participants. Terminated before completion.
9 May 2025
Quick facts
| Lead sponsor | Istituto Ortopedico Rizzoli |
|---|---|
| Phase | NA |
| Status | Terminated |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 49 |
| Start date | 22 February 2021 |
| Primary completion | 9 May 2025 |
| Estimated completion | 9 May 2025 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Tibial osteotomy with Tranexamic acid — full drug profile →
- Tibial osteotomy without Tranexamic acid
Conditions studied
- Monocompartimental Tibiofemoral Osteoarthritis — all drugs for Monocompartimental Tibiofemoral Osteoarthritis →
- Osteoarthritis — all drugs for Osteoarthritis →
Sponsor
Istituto Ortopedico Rizzoli — full company profile →
Who can join
Adults 18 to 70, any sex, with Monocompartimental Tibiofemoral Osteoarthritis or Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A randomised controlled double-blind clinical trial focused on the evaluation of the effectiveness of the tranexamic acid on bleeding, pain and wound complications reduction in tibial osteotomies. All the 84 included patients will be randomized in one of the two arms, will undergo to a tibial osteotomy and then will prospectively evaluate at different follow ups until 60 days post-surgery
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04785651
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04785651 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Istituto Ortopedico Rizzoli
- Last refreshed: 22 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04785651.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing