NCT04784832: IMAP-TMS

TMS-based Assessment of Mental Training Effects on Motor Learning in Healthy Participants

Recruiting now NA Last updated 3 January 2025

What this trial tests

NA trial testing Transcranial magnetic stimulation in Motor Learning in 556 participants. Currently enrolling.

Timeline

8 April 2024

Primary endpoint
7 April 2027

7 April 2027

Quick facts

Lead sponsor	Institut National de la Santé Et de la Recherche Médicale, France
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	factorial
Masking	none
Primary purpose	basic science
Enrollment	556
Start date	8 April 2024
Primary completion	7 April 2027
Estimated completion	7 April 2027
Sites	1 location across France

Drugs / interventions tested

• Transcranial magnetic stimulation — full drug profile →
• Peripheral Nerve Stimulation
• Transcranial direct current stimulation
• Paired Associative Stimulation
• Wrist
• Robotic arm
• Cervicomedullar stimulation
• Physical training
• Mental training

Conditions studied

• Motor Learning — all drugs for Motor Learning →

Sponsor

Institut National de la Santé Et de la Recherche Médicale, France — full company profile →

Who can join

Adults 18 to 60, any sex, with Motor Learning. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The general purpose of this research project is to analyze the specific role of motor imagery on motor learning, assessed through corticospinal excitability measurements and behavioral data collection. This project is based on four sequences. For Sequence 1, the main objective is to examine the effect of mental training on movement speed and accuracy in a manual motor sequence task, as well as the influence of sensory feedback in immediate post-test (i.e., execution of a similar, but not identical, manual motor sequence, other manual tasks) on performance in delayed post-test. The secondary objective will be to examine corticospinal changes (i.e., amplitude of motor evoked potentials) induced by mental training, by measuring the amplitude of motor evoked potentials before and after mental training. For Sequence 2, the main objective is to examine the impact of a motor disturbance induced by a robotic arm at different intervals during the motor imagery process. The secondary objective will be to examine the corticospinal changes (i.e. amplitude of evoked motor potentials) induced by mental training as a function of the applied perturbations, before and after perturbation. For Sequence 3, the main objective will be to examine the influence of neuroplasticity on the quality of mental training. More specifically, the investigators will study the links between brain plasticity and motor learning through mental training. The secondary objective will be to examine the corticospinal changes (i.e. amplitude of evoked motor potentials) induced by mental training at different levels of the neuromuscular system (cortical, cervicomedullar, peripheral) after a training period. For Sequence 4, the main objective will be to examine the effect of short-term arm-immobilization of on the retention of motor learning induced by mental training. The secondary objective will be to examine the corticospinal changes (i.e., amplitude of motor evoked potentials) induced by of short-term arm-immobilization, or by transcranial direct current stimulation (tDCS), on motor learning. The results of this fundamental research project will allow a better understanding of neurophysiological and behavioral mechanisms that underlie motor learning through motor imagery. The results will allow to efficiently consider inter-individual specificities and will thus open up to clinical research perspectives, towards the establishment of adapted motor rehabilitation protocols.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.