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NCT04782908: HERACLES-HFpEF
Hemodynamic Implications of Transcatheter Tricuspid Valve Repair in HFpEF Patients
NA trial testing Transcatheter tricuspid valve edge-to-edge repair in Congestive Heart Failure in 20 participants. Status unknown.
30 March 2022
Quick facts
| Lead sponsor | Heart Center Leipzig - University Hospital |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 20 |
| Start date | 1 March 2021 |
| Primary completion | 30 March 2022 |
| Estimated completion | 30 June 2022 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Transcatheter tricuspid valve edge-to-edge repair
Conditions studied
- Congestive Heart Failure — all drugs for Congestive Heart Failure →
- Tricuspid Regurgitation — all drugs for Tricuspid Regurgitation →
Sponsor
Heart Center Leipzig - University Hospital
Who can join
18 and older, any sex, with Congestive Heart Failure or Tricuspid Regurgitation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of the study is to investigate the pathophysiological implications of transcatheter tricuspid valve edge-to-edge repair in patient with heart failure and preserved ejection fraction and severe tricuspid regurgitation. Changes in right- and left-ventricular function as well as the interventricular dependence will be analysed on a multimodal basis including pressure-volume loop analysis and cardiac magnetic resonance imaging.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Implications of tricuspid regurgitation and right ventricular volume overload in patients with heart failure with preserved ejection fraction.
Kresoja KP, Rosch S, Schöber AR, Fengler K, et al · · 2024 · cited 32× · PMID 38462987 · DOI 10.1002/ejhf.3195 -
Running on empty: Factors underpinning impaired cardiac output reserve in heart failure with preserved ejection fraction.
Sagmeister P, Rosch S, Fengler K, Kresoja KP, et al · · 2025 · cited 3× · PMID 38421268 · DOI 10.1113/ep091776
Verify or expand the search:
- PubMed search for NCT04782908
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Congestive Heart Failure
Currently open trials in the same condition.
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- NCT06526884 — Quasi-Randomized Evaluation of the UCLA Next Day Clinic (NDC) · NA · active not recruiting
- NCT06495892 — PVP-Guided Decongestive Therapy in HF 2 · Phase 4 · recruiting
- NCT06374277 — Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence · NA · recruiting
- NCT05971225 — Verifying Remote Monitoring Effect on Net Cardiovascular Outcome; RemoteVerify (RêVe) · NA · recruiting
Other Heart Center Leipzig - University Hospital trials
Trials by the same sponsor.
- NCT07462624 — REpeat Intervention For Failed Surgical BioProsthEtic AorTic Valves (REPEAT) · NA · recruiting
- NCT06845579 — Prediction of Blood Pressure Outcomes Following Renal Denervation (PREDICT-RDN) · NA · recruiting
- NCT07049289 — Telemonitoring in Arterial Hypertension · NA · active not recruiting
- NCT04737317 — Diagnostic Criteria in Cardiac Sarcoidosis · recruiting
- NCT05793398 — Biomaterial Collection - and Analysis in Cardiac Sarcoidosis · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04782908 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Heart Center Leipzig - University Hospital
- Last refreshed: 19 April 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04782908.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing