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NCT07462624: REPEAT
REpeat Intervention For Failed Surgical BioProsthEtic AorTic Valves (REPEAT)
NA trial testing Transfemoral transcatheter valve-in-valve implantation in Degenerative Aortic Valve Disease in 890 participants. Currently enrolling.
30 September 2033
Quick facts
| Lead sponsor | Heart Center Leipzig - University Hospital |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 890 |
| Start date | 10 November 2025 |
| Primary completion | 30 September 2033 |
| Estimated completion | 30 September 2033 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Transfemoral transcatheter valve-in-valve implantation
- Surgical redo aortic valve replacement
Conditions studied
- Degenerative Aortic Valve Disease — all drugs for Degenerative Aortic Valve Disease →
Sponsor
Heart Center Leipzig - University Hospital
Who can join
Adults 18 to 75, any sex, with Degenerative Aortic Valve Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The overall hypothesis is that redo aortic valve replacement (rAVR) is superior to valve-invalve transcatheter aortic valve replacement (ViV-TAVR) for the composite endpoint of freedom from all-cause mortality, all-cause stroke, myocardial infarction, and rehospitalization for heart failure or aortic valve re-intervention at 5 years.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07462624
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Degenerative Aortic Valve Disease
Currently open trials in the same condition.
- NCT03383445 — Transcatheter Aortic Valve Replacement Versu Surgical Aortix Valve Replacement for Treating Elderly Patients With Severe · NA · active not recruiting
Other Heart Center Leipzig - University Hospital trials
Trials by the same sponsor.
- NCT06845579 — Prediction of Blood Pressure Outcomes Following Renal Denervation (PREDICT-RDN) · NA · recruiting
- NCT07049289 — Telemonitoring in Arterial Hypertension · NA · active not recruiting
- NCT04737317 — Diagnostic Criteria in Cardiac Sarcoidosis · recruiting
- NCT05793398 — Biomaterial Collection - and Analysis in Cardiac Sarcoidosis · not yet recruiting
- NCT05456789 — Catheter-interventional Treatment of Pulmonary Embolism · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07462624 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Heart Center Leipzig - University Hospital
- Last refreshed: 10 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07462624.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing